Association of Sleep Disorders with Nonalcoholic Fatty Liver Disease (NAFLD): A Population-based Study

Journal of Clinical and Experimental Hepatology
Heshaam M MirZobair M Younossi

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease. In smaller studies, sleep apnea has been previously associated with NAFLD. The aim of this study was to assess the prevalence and independent associations of sleep disorders in patients with NAFLD using recent population-based data. Three cycles of the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2010 were used. The diagnosis of NAFLD was established as elevated liver enzymes in the absence of all other causes of chronic liver disease. Sleep disorders were diagnosed using sleep disorder questionnaires completed by NHANES participants, and included self-reported history of sleep apnea, insomnia, and restless leg syndrome. The prevalence of sleep disorders was compared between those with and without NAFLD. A total of 10,541 adult NHANES participants with complete demographic, clinical, and laboratory data were included. Of those, 15.0% had NAFLD and 7.2% reported having sleep disorders. Of those with sleep disorders, 64.7% reported history of sleep apnea, 16.0% had history of insomnia, and 4.0% had restless leg syndrome. Individuals with NAFLD were more likely to be male (53.8% vs. 45.7%, P < 0.0001), obese ...Continue Reading

Citations

Dec 26, 2018·Journal of Clinical Medicine·Hiroki NishikawaShuhei Nishiguchi
Sep 9, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Francesca M TrovatoGuglielmo M Trovato
Aug 9, 2020·Life·Hiroki NishikawaHiroko Iijima
Dec 14, 2016·World Journal of Hepatology·Francesca M TrovatoDaniela Catalano
Oct 5, 2020·Acta Psychiatrica Scandinavica·Ophelia GodinUNKNOWN FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators
Feb 13, 2021·Journal of Clinical Medicine·Kristoffer KjærgaardKaren Louise Thomsen
Jul 18, 2021·The Lancet. Gastroenterology & Hepatology·Thomas MarjotMatthew J Armstrong

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