Association of smoking and cardiometabolic parameters with albuminuria in people with type 2 diabetes mellitus: a systematic review and meta-analysis

Acta Diabetologica
Debasish KarSamuel Seidu

Abstract

Smoking is a strong risk factor for albuminuria in people with type 2 diabetes mellitus (T2DM). However, it is unclear whether this sequela of smoking is brought about by its action on cardiometabolic parameters or the relationship is independent. The aim of this systematic review is to explore this relationship. Electronic databases on cross-sectional and prospective studies in Medline and Embase were searched from January 1946 to May 2018. Adult smokers with T2DM were included, and other types of diabetes were excluded. A random effects meta-analysis of 20,056 participants from 13 studies found that the odds ratio (OR) of smokers developing albuminuria compared to non-smokers was 2.13 (95% CI 1.32, 3.45). Apart from smoking, the odds ratio of other risk factors associated with albuminuria were: age 1.24 (95% CI 0.84, 1.64), male sex 1.39 (95% CI 1.16, 1.67), duration of diabetes 1.78 (95% CI 1.32, 2.23), HbA1c 0.63 (95% CI 0.45, 0.81), SBP 6.03 (95% CI 4.10, 7.97), DBP 1.85 (95% CI 1.08, 2.62), total cholesterol 0.06 (95% CI - 0.05, 0.17) and HDL cholesterol - 0.01 (95% CI - 0.04, 0.02), triglyceride 0.22 (95% CI 0.12, 0.33) and BMI 0.40 (95% CI 0.00-0.80). When the smoking status was adjusted in a mixed effect meta-regressio...Continue Reading

References

Jun 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S SavageR W Schrier
Apr 1, 1996·Journal of Internal Medicine·P T SawickiM Berger
Dec 31, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D Di LandroG F Romagnoli
Oct 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K A KohlerJ R Boring
Apr 20, 2001·Diabetes Research and Clinical Practice·L T PijlsJ T van Eijk
Sep 26, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C M FerraraA P Goldberg
Feb 13, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Temduang Chuahirun, Donald E Wesson
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Oct 25, 2002·Journal of the American Society of Nephrology : JASN·Bruno BaggioPaola Fioretto
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Temduang ChuahirunDonald E Wesson
Jul 2, 2003·Diabetes Care·Graziella BrunoUNKNOWN Casale Monferrato Study
Dec 20, 2003·Journal of the American Society of Nephrology : JASN·Stephan R Orth
Feb 11, 2004·The American Journal of the Medical Sciences·Temduang ChuahirunDonald E Wesson
Jun 30, 2004·Diabetes & Metabolism·P M NilssonUNKNOWN Steering Committee of the Swedish National Diabetes Register
Feb 17, 2005·Diabetes Research and Clinical Practice·J CederholmUNKNOWN Steering Committee of the Swedish National Diabetes Register
Jul 28, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stephan R OrthPaolo Ferrari
Jul 27, 2006·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·G N ThomasJ C N Chan
Jan 17, 2007·Metabolism: Clinical and Experimental·Futoshi AnanHironobu Yoshimatsu
Dec 7, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Ian H de BoerBryan Kestenbaum
Apr 17, 2008·The American Journal of the Medical Sciences·Kantima PhisitkulDonald E Wesson
May 13, 2008·Diabetes & Metabolism·Ivan Berlin
Nov 26, 2008·Clinical Chemistry·W Greg MillerUNKNOWN National Kidney Disease Education Program-IFCC Working Group on Standardization of Albumin in Urine
Feb 7, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G ZoppiniM Muggeo
Mar 17, 2009·Bosnian Journal of Basic Medical Sciences·Belma Ascić-ButurovićMehmed Kulić
Mar 2, 2010·Diabetes Research and Clinical Practice·P PrashanthUNKNOWN DEMAND Gulf Study Investigators
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·C C HsuH-Y Chang
Oct 14, 2010·Journal of General Internal Medicine·Michael R Grey

❮ Previous
Next ❯

Software Mentioned

metafor
Cochrane Collaboration Review Manager
R

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.