Association of smoking with abdominal adipose deposition and muscle composition in Coronary Artery Risk Development in Young Adults (CARDIA) participants at mid-life: A population-based cohort study

PLoS Medicine
James G TerryJohn Jeffrey Carr

Abstract

Smokers have lower risk of obesity, which some consider a "beneficial" side effect of smoking. However, some studies suggest that smoking is simultaneously associated with higher central adiposity and, more specifically, ectopic adipose deposition. Little is known about the association of smoking with intermuscular adipose tissue (IMAT), an ectopic adipose depot associated with cardiovascular disease (CVD) risk and a key determinant of muscle quality and function. We tested the hypothesis that smokers have higher abdominal IMAT and lower lean muscle quality than never smokers. We measured abdominal muscle total, lean, and adipose volumes (in cubic centimeters) and attenuation (in Hounsfield units [HU]) along with subcutaneous (SAT) and visceral adipose tissue (VAT) volumes using computed tomography (CT) in 3,020 middle-aged Coronary Artery Risk Development in Young Adults (CARDIA) participants (age 42-58, 56.3% women, 52.6% white race) at the year 25 (Y25) visit. The longitudinal CARDIA study was initiated in 1985 with the recruitment of young adult participants (aged 18-30 years) equally balanced by female and male sex and black and white race at 4 field centers located in Birmingham, AL, Chicago, IL, Minneapolis, MN, and Oakl...Continue Reading

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Citations

Feb 2, 2021·The Journal of Clinical Endocrinology and Metabolism·Duke AppiahErica P Gunderson
May 1, 2021·International Journal of Environmental Research and Public Health·Sung Hoon JeongEun-Cheol Park
May 28, 2021·Journal of Family Medicine and Primary Care·Eyad MakkawyTahani Altamimi
Aug 31, 2021·Acta Psychiatrica Scandinavica·Emily SmithSri Mahavir Agarwal

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Methods Mentioned

BETA
X-ray
biopsies

Software Mentioned

Medical Image Processing , Analysis , and Visualization ( MIPAV )
MIPAV
CARDIA

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