Association of SPINK1 gene mutation and CFTR gene polymorphisms in patients with pancreas divisum presenting with idiopathic pancreatitis

Journal of Clinical Gastroenterology
Pramod Kumar GargShivaram S Shastri

Abstract

Pancreas divisum has been associated with idiopathic pancreatitis. However, the causal association remains controversial. To study the gene mutations in patients with pancreas divisum presenting with idiopathic pancreatitis. All consecutive patients with pancreas divisum presenting with recurrent pancreatitis were included in the study. Fifty healthy volunteers, 30 patients with chronic pancreatitis, and 14 patients with idiopathic recurrent acute pancreatitis without pancreas divisum served as controls. Patients and controls were tested for cationic trypsiongen gene, CFTR gene and SPINK1 gene mutations. Of the 12 patients with pancreas divisum and idiopathic pancreatitis, 4 had SPINK1 N34S gene mutation-3 were heterozygous and 1 was homozygous, and 1 had P55S mutation compared with 1 of 50 healthy controls with N34S mutation (P=0.001). The frequency of SPINK1 mutation was similar among patients with pancreas divisum and pancreatitis (41.6%), chronic pancreatitis (43.3%), and recurrent acute pancreatitis without pancreas divisum (35.7%). Five patients with pancreas divisum had polymorphisms in the CFTR gene. Patients with pancreas divisum presenting with idiopathic pancreatitis had a higher frequency of SPINK1 gene mutation com...Continue Reading

References

Nov 1, 1977·American Journal of Surgery·J A Gregg
Feb 11, 1975·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·R L MacCartyH C Carlson
Mar 1, 1991·Endoscopy·D L Carr-Locke
Jan 1, 1988·Digestive Diseases·M DelhayeM Cremer
Dec 1, 1984·The British Journal of Surgery·R C RussellP B Cotton
Jan 1, 1993·Gastrointestinal Endoscopy·G A LehmanR H Hawes
Aug 26, 1998·Molecular Pathology : MP·S M BellN J Lench
Sep 3, 1998·The New England Journal of Medicine·N SharerJ Braganza
Sep 3, 1998·The New England Journal of Medicine·J A CohnP S Jowell
Jun 27, 2000·American Journal of Medical Genetics·M KabraA Wallace
Aug 15, 2000·Gut·L Quest, M Lombard
Jan 1, 1961·The Anatomical Record·W DAWSON, J LANGMAN
Jul 6, 2004·The American Journal of Gastroenterology·C P ChoudariGlen A Lehman
Aug 17, 2004·The American Journal of Gastroenterology·Andres GelrudSteven D Freedman
Aug 26, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Pramod Kumar GargKaushal Madan

❮ Previous
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Citations

Apr 29, 2010·Current Gastroenterology Reports·Christopher D Jolley
Jan 12, 2011·Current Gastroenterology Reports·Matthew J DiMagno, Erik-Jan Wamsteker
Feb 14, 2012·Current Gastroenterology Reports·Pramod Kumar Garg
Apr 22, 2014·Abdominal Imaging·Kumaresan SandrasegaranStuart Sherman
Oct 2, 2013·Gastrointestinal Endoscopy Clinics of North America·Jason R Roberts, Joseph Romagnuolo
Feb 19, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marco MontagnaniVilma Mantovani
May 23, 2014·Journal of Hepato-biliary-pancreatic Sciences·Praveer RaiRakesh Aggarwal
Dec 6, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Giulia Martina CavestroPier Alberto Testoni
Jan 4, 2015·The Journal of Pediatrics·Sarah Jane SchwarzenbergAliye Uc
Jul 3, 2016·Current Treatment Options in Gastroenterology·Piyush Somani, Udayakumar Navaneethan
Mar 16, 2017·Nature Reviews. Gastroenterology & Hepatology·Sohail Z Husain, Arvind I Srinath
Jan 16, 2018·Gastroenterology Research and Practice·Yong ChenXiao Ming Zhang
Dec 14, 2011·The American Journal of Gastroenterology·Caroline BertinPhilippe Lévy
Feb 7, 2012·The American Journal of Gastroenterology·Matthew J DiMagno, Eugene P Dimagno
Mar 19, 2011·Journal of Pediatric Gastroenterology and Nutrition·Yeoun Joo LeeHan-Wook Yoo
Aug 29, 2009·Journal of Clinical Gastroenterology·Nalini M Guda, Martin L Freeman
Jun 6, 2019·Clinical and Translational Gastroenterology·David C Whitcomb, UNKNOWN North American Pancreatitis Study Group
Dec 17, 2014·Clinical Endoscopy·Sung Ik PyeonKong Jin Oh
Oct 31, 2019·Expert Review of Gastroenterology & Hepatology·Aditya GuttaStuart Sherman
Nov 19, 2011·Journal of Pediatric Gastroenterology and Nutrition·Mutaz SultanNarayanan Venkatasubramani
Jun 5, 2018·Journal of Clinical Gastroenterology·Tom K LinAliye Uc
Dec 18, 2014·World Journal of Gastroenterology : WJG·Alberto MarianiPier Alberto Testoni
Apr 15, 2016·Pancreas·Eugene P DiMagno, Matthew J DiMagno
Mar 2, 2017·Therapeutic Advances in Gastroenterology·Zachary Zator, David C Whitcomb
Sep 21, 2018·Current Treatment Options in Gastroenterology·Soumya Jagannath, Pramod Kumar Garg
Nov 12, 2016·World Journal of Gastroenterology : WJG·Takana Yamakawa HayashiKuni Ohtomo
Nov 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·Tom K LinMaisam Abu-El-Haija
Aug 4, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Mitsuyoshi SuzukiToshiaki Shimizu
Feb 5, 2019·Gastroenterology·Aliye Uc, Sohail Z Husain
Dec 7, 2018·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Serghei Covantev

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