Association of splenectomy with postoperative complications in patients with proximal gastric and gastroesophageal junction cancer

Annals of Surgical Oncology
Jürgen WeitzMartin S Karpeh

Abstract

Splenectomy has been associated with increased morbidity after gastrectomy for gastric cancer. Resection of proximal versus distal tumors is associated with a higher morbidity. Because splenectomy is more commonly performed in resection of proximal tumors, these analyses may be biased. The aim of this study was to describe the association of splenectomy with complications in patients undergoing resection of proximal gastric and gastroesophageal junction (GEJ) cancers. From July 1985 to August 2001, 335 patients underwent resection of proximal gastric or GEJ (type II and III) cancers. Clinical and pathologic factors were retrieved from a prospective database. Overall morbidity was 59% (infectious complications, 41%; noninfectious complications, 36%), and mortality was 4.5%. Splenectomy was associated with a higher rate of infectious complications (57% vs. 33%; P <.01) but not of noninfectious complications (39% vs. 34%; not significant) or mortality (4% vs. 5%; not significant). Splenectomy was also associated with a higher rate of infectious complications on multivariate analysis (hazard ratio, 2.4; P <.01). Morbidity after resection of proximal gastric and GEJ cancer is significant; splenectomy is associated with increased mor...Continue Reading

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Citations

Nov 13, 2009·World Journal of Gastroenterology : WJG·Kun YangJia-Ping Chen
Sep 8, 2006·World Journal of Surgery·Jong Han KimChong Suk Kim
Dec 4, 2008·Annals of Surgical Oncology·Fabio CarboniEugenio Santoro
Feb 26, 2009·Annals of Surgical Oncology·Suk Hee ShinSung Kim
Aug 18, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Donghui ZhaoZhe Sun
May 15, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·B B PultrumJ T H M Plukker
Sep 27, 2006·The Journal of Thoracic and Cardiovascular Surgery·K Robert ShenPeter C Pairolero
Sep 5, 2018·Asia-Pacific Journal of Clinical Oncology·Qiuhong WangLiansheng Zheng
May 22, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Chikara KunisakiHiroshi Shimada
Dec 1, 2009·The Indian Journal of Surgery·Manas Kumar RoySanjay Kumar Dubey
Nov 7, 2019·Journal of Surgical Oncology·Felipe J F CoimbraWilson L da Costa
Jul 5, 2019·International Journal of Surgery·Zhengyan LiQingchuan Zhao

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