Association of Stress-Related Disorders With Subsequent Neurodegenerative Diseases.

JAMA Neurology
Huan SongFang Fang

Abstract

Posttraumatic stress disorder (PTSD) has been associated with increased risk for dementia. Less is known, however, about other stress-related disorders and their associations with neurodegenerative diseases. To examine the association between stress-related disorders and risk for neurodegenerative diseases. This population-matched and sibling cohort study was conducted in Sweden using data from nationwide health registers, including the Swedish National Patient Register. Individuals who received their first diagnosis of stress-related disorders between January 1, 1987, and December 31, 2008, were identified. Individuals who had a history of neurodegenerative diseases, had conflicting or missing information, had no data on family links, or were aged 40 years or younger at the end of the study were excluded. Individuals with stress-related disorders were compared with the general population in a matched cohort design; they were also compared with their siblings in a sibling cohort. Follow-up commenced from the age of 40 years or 5 years after the diagnosis of stress-related disorders, whichever came later, until the first diagnosis of a neurodegenerative disease, death, emigration, or the end of follow-up (December 31, 2013), whi...Continue Reading

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Citations

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Jul 3, 2021·International Journal of Environmental Research and Public Health·Lilian Calderón-GarcidueñasPartha S Mukherjee

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