Association of sugar-based carboranes with cationic liposomes: an electron spin resonance and light scattering study

Biochimica Et Biophysica Acta
Sara MorandiGiacomo Martini

Abstract

The possibility of cationic (di-oleoyltrimethylammonium propane, DOTAP)/(L-alpha-dioleoylphosphatidyl-ethanolamine, DOPE) liposomes to act as carriers of boronated compounds such as 1,2-dicarba-closo-dodecaboran(12)-1-ylmethyl](beta-D-galactopyranosyl)-(1-->4)-beta-D-glucopyranoside and 1,2-di-(beta-D-gluco-pyranosyl-ox)methyl-1,2-dicarba-closo-dodeca-borane(12) has been investigated by Electron Spin Resonance (ESR) of n-doxyl stearic acids (n-DSA) and Quasi-Elastic Light Scattering (QELS). Both these carboranes have potential use in Boron Neutron Capture Therapy (BNCT), which is a targeted therapy for the treatment of radiation resistant tumors. They were shown to give aggregation both in plain water and in saline solution. Carborane aggregates were, however, disrupted when DOTAP/DOPE liposome solutions were used as dispersing agents. The computer analysis of the ESR spectra from carborane-loaded liposomes allowed to establish an increase of the order degree in the liposome bilayer with increasing carborane concentration, together with a decreased mobility. The same discontinuities of both correlation time and order parameter with respect to temperature variations were observed in carborane-containing and carborane-free liposo...Continue Reading

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Citations

Apr 27, 2013·Future Medicinal Chemistry·Srinivasa R MarepallyGeorge W Kabalka
Apr 23, 2008·Expert Opinion on Drug Delivery·Hironobu YanagiëHiroyuki Takahashi
Dec 18, 2008·Physical Chemistry Chemical Physics : PCCP·Giacomo Martini, Laura Ciani
Aug 8, 2009·Physics in Medicine and Biology·Melanie KetteringIngrid Hilger
Jan 29, 2021·ChemMedChem·Marta GozziEvamarie Hey-Hawkins
Feb 9, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Pavel MatejícekZbigniew J Lesnikowski

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