Association of symptoms and severity of rift valley fever with genetic polymorphisms in human innate immune pathways

PLoS Neglected Tropical Diseases
Amy G HiseCatherine M Stein

Abstract

Multiple recent outbreaks of Rift Valley Fever (RVF) in Africa, Madagascar, and the Arabian Peninsula have resulted in significant morbidity, mortality, and financial loss due to related livestock epizootics. Presentation of human RVF varies from mild febrile illness to meningoencephalitis, hemorrhagic diathesis, and/or ophthalmitis with residual retinal scarring, but the determinants for severe disease are not understood. The aim of the present study was to identify human genes associated with RVF clinical disease in a high-risk population in Northeastern Province, Kenya. We conducted a cross-sectional survey among residents (N = 1,080; 1-85 yrs) in 6 villages in the Sangailu Division of Ijara District. Participants completed questionnaires on past symptoms and exposures, physical exam, vision testing, and blood collection. Single nucleotide polymorphism (SNP) genotyping was performed on a subset of individuals who reported past clinical symptoms consistent with RVF and unrelated subjects. Four symptom clusters were defined: meningoencephalitis, hemorrhagic fever, eye disease, and RVF-not otherwise specified. SNPs in 46 viral sensing and response genes were investigated. Association was analyzed between SNP genotype, serology ...Continue Reading

References

May 1, 1989·Reviews of Infectious Diseases·C J PetersP B Jahrling
Oct 1, 1988·Microbial Pathogenesis·G W Anderson, C J Peters
Nov 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K E MogensenG Uzé
Oct 24, 2000·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control and Prevention (CDC)
Dec 29, 2000·Nature·H HemmiS Akira
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·Z CaoD V Goeddel
Sep 14, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·K Takeda, S Akira
Sep 29, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M SandrockG Kochs
Oct 12, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Isaäcson
Mar 19, 2002·Emerging Infectious Diseases·Christopher W WoodsUNKNOWN World Health Organization Hemorrhagic Fever Task Force
Aug 7, 2002·Journal of Virology·Karen BiebackSibylle Schneider-Schaulies
Mar 29, 2003·Journal of Virology·Teresa ComptonRobert W Finberg
Aug 6, 2003·The Journal of Experimental Medicine·Jennifer LundAkiko Iwasaki
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Mar 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer M LundRichard A Flavell
Nov 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·J AndrejevaR E Randall
Dec 15, 2004·Microbes and Infection·Robert W Finberg, Evelyn A Kurt-Jones
Feb 5, 2005·Ophthalmology·Ali Al-HazmiNasser Ahmed
May 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Gregory S HagemanRando Allikmets
Jul 26, 2005·Immunity·Hiroki KatoShizuo Akira
Aug 30, 2005·Nature Immunology·Taro KawaiShizuo Akira
Sep 13, 2005·Molecular Cell·Liang-Guo XuHong-Bing Shu
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Feb 14, 2006·Cell Research·Rashu B SethZhijian J Chen
May 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Leonid GitlinMarco Colonna
Jun 21, 2006·The Journal of Experimental Medicine·Himanshu KumarShizuo Akira
Oct 14, 2006·Science·Veit HornungGunther Hartmann
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian B GowenRobert W Sidwell

❮ Previous
Next ❯

Citations

Nov 1, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amber M PaulFengwei Bai
Sep 28, 2018·Journal of Virology·Jessica R HarmonAnita K McElroy
Jul 17, 2019·The Journal of General Virology·Daniel WrightGeorge M Warimwe
Apr 4, 2020·Journal of Biochemical and Molecular Toxicology·Yong YangLi Liu
Jan 24, 2020·Annals of Clinical Microbiology and Antimicrobials·Emilie JavelleFabrice Simon
Oct 30, 2020·MSphere·Dominique J BarbeauAnita K McElroy
Jan 16, 2021·Journal of Leukocyte Biology·Nicole A de WeerdPaul J Hertzog

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
ELISA

Software Mentioned

PLINK
SPSS

Related Concepts

Related Feeds

Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.