Association of Symptoms of Depression With Cardiovascular Disease and Mortality in Low-, Middle-, and High-Income Countries.

JAMA Psychiatry
Selina RajanProspective Urban Rural Epidemiology (PURE) Study Investigators

Abstract

Depression is associated with incidence of and premature death from cardiovascular disease (CVD) and cancer in high-income countries, but it is not known whether this is true in low- and middle-income countries and in urban areas, where most people with depression now live. To identify any associations between depressive symptoms and incident CVD and all-cause mortality in countries at different levels of economic development and in urban and rural areas. This multicenter, population-based cohort study was conducted between January 2005 and June 2019 (median follow-up, 9.3 years) and included 370 urban and 314 rural communities from 21 economically diverse countries on 5 continents. Eligible participants aged 35 to 70 years were enrolled. Analysis began February 2018 and ended September 2019. Four or more self-reported depressive symptoms from the Short-Form Composite International Diagnostic Interview. Incident CVD, all-cause mortality, and a combined measure of either incident CVD or all-cause mortality. Of 145 862 participants, 61 235 (58%) were male and the mean (SD) age was 50.05 (9.7) years. Of those, 15 983 (11%) reported 4 or more depressive symptoms at baseline. Depression was associated with incident CVD (hazard ratio...Continue Reading

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Citations

Jan 8, 2021·Current Problems in Cardiology·Daniel PiskorzUNKNOWN CorCOVID Latam Study Investigators
Jan 13, 2021·Psychological Medicine·Hillary L DitmarsMichael J Lyons
Oct 2, 2020·Canadian Journal of Physiology and Pharmacology·Carlotta Baroni, Vincenzo Lionetti
Nov 17, 2020·Journal of European CME·Reinhard GriebenowRobert Schäfer
Feb 18, 2021·JAMA Psychiatry·Jasmin WertzTerrie E Moffitt
Apr 8, 2021·International Review of Psychiatry·Hugo Senra, Susan McPherson
Jul 31, 2021·Journal of the American College of Cardiology·Jean-Pierre DesprésPaul Poirier

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