Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology

Journal of Shoulder and Elbow Surgery
Geoffrey D AbramsJeremy Sokolove

Abstract

We hypothesized that patients with full-thickness rotator cuff tears would have greater synovial inflammation compared with those without rotator cuff tear pathology, with gene expression relating to histologic findings. Synovial sampling was performed in 19 patients with full-thickness rotator cuff tears (RTC group) and in 11 patients without rotator cuff pathology (control group). Cryosections were stained and examined under light microscopy and confocal fluorescent microscopy for anti-cluster CD45 (common leukocyte antigen), anti-CD31 (endothelial), and anti-CD68 (macrophage) cell surface markers. A grading system was used to quantitate synovitis under light microscopy, and digital image analysis was used to quantify the immunofluorescence staining area. Quantitative polymerase chain reaction was performed for validated inflammatory markers. Data were analyzed with analysis of covariance, Mann-Whitney U, and Spearman rank order testing, with significance set at α = .05. The synovitis score was significantly increased in the RTC group compared with controls. Immunofluorescence demonstrated significantly increased staining for CD31, CD45, and CD68 in the RTC vs control group. CD45+/68- cells were found perivascularly, with CD4...Continue Reading

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Citations

Sep 27, 2018·JBJS Reviews·Jinjin MaKathleen A Derwin
May 17, 2019·British Medical Bulletin·Lucio CipollaroNicola Maffulli
Sep 28, 2017·Techniques in Shoulder & Elbow Surgery·Adam C AbrahamStavros Thomopoulos
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Feb 6, 2017·Clinical Orthopaedics and Related Research·Jorge H AssunçãoArnaldo A Ferreira Neto
Dec 7, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Du-Han KimChul-Hyun Cho
Mar 28, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Brittany L TaylorJoseph Bernstein
Sep 13, 2020·Journal of Shoulder and Elbow Surgery·Lars Henrik FrichKate Lykke Lambertsen
Mar 23, 2021·Clinics in Orthopedic Surgery·Doohyung LeeBong Gun Lee
Sep 24, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chengcheng FuWoojin M Han

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