May 24, 2012

Association of systemic inflammation with marked changes in particulate air pollution in Beijing in 2008

Toxicology Letters
Xiaohua XuQinghua Sun

Abstract

Many studies have linked ambient fine particulate matter (aerodynamic diameters less than 2.5 μm, PM₂.₅) air pollution to increased morbidity and mortality of cardiovascular diseases in the general population, but the biologic mechanisms of these associations are yet to be elucidated. In this study, we aimed to evaluate the relationship between daily variations in exposure to PM₂.₅ and inflammatory responses in mice during and for 2 months after the Beijing Olympic Games. Male C57BL/6 mice were exposed to Beijing PM₂.₅ or filtered air (FA) in 2008 during the 2 months of Beijing Olympic and Paralympic Games, and for 2 months after the end of the Games. During the Games, circulating monocyte chemoattractant protein 1 and interleukin 6 were increased significantly in the PM₂.₅ exposure group, when compared with the FA control group, although there were no significant inter-group differences in tumor necrosis factor-α or interferon-γ, or in macrophages, neutrophils or lymphocytes in the spleen or thymus between these 2 groups. However, macrophages were significantly increased in the lung and visceral fat with increasing PM₂.₅. After the Olympic Games, there were no significant PM₂.₅-associated differences for macrophages, neutrophi...Continue Reading

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Mentioned in this Paper

Retroperitoneal Fat
T-Lymphocyte
Neutrophil Band Cells
Systemic Inflammatory Response Syndrome
Lung
Spleen
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Epididymis
Neoplasm of Uncertain or Unknown Behavior of Thymus
Recombinant Interleukin-10

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