Association of Systemic Inflammatory and Anti-inflammatory Responses with Adverse Outcomes in Acute Pancreatitis: Preliminary Results of an Ongoing Study

Digestive Diseases and Sciences
Deepesh SharmaRupjyoti Talukdar

Abstract

This paper reports preliminary data of an ongoing study that evaluates the association of systemic inflammatory response (SIRS) with early severe acute pancreatitis (ESAP) and compensatory anti-inflammatory response syndrome (characterized by HLA-DR down-regulation) with infected pancreatic necrosis (IPN). Consecutive patients presenting within 72 h of symptom onset with organ dysfunction and/or local complications were included. Following parameters were recorded: demographics, etiology, SIRS, APACHE II, creatinine, BUN. Circulating IL-8, IL-6, IL-10, TNF-alpha concentrations and expression of HLA-DR and IL-10 by qRT-PCR in PBMCs were measured. Strength of associations of cytokine concentration and HLA-DR/IL-10 expression with outcomes was expressed as Hedges' G and relative risk (95% CI). Twenty-eight patients (10 MSAP; 18 SAP) fulfilled inclusion criteria. Twelve patients had ESAP and eight presented with organ failure. Admission SIRS worsened in eight (28.6%) patients over 48 h. Sixteen (57.1%) patients developed primary IPN. Twenty-one (75%) patients had HLA-DR down-regulation during the first week, which persisted to the second week in 12 (42.9%) patients. IL-8, IL-6, and TNF-α progressively increased from healthy control...Continue Reading

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Citations

Mar 20, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Rupjyoti Talukdar
Mar 21, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Chaochao TanYing Huang
Mar 22, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ruling ZhangJing Xue
May 30, 2019·Nature Reviews. Gastroenterology & Hepatology·Peter J Lee, Georgios I Papachristou
Nov 25, 2020·Current Treatment Options in Gastroenterology·Peter J Lee, Georgios I Papachristou
May 30, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Rupjyoti TalukdarD Nageshwar Reddy
Jul 9, 2021·Therapeutics and Clinical Risk Management·Hong Peng LiQing Yun Li

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