Association of T and non-T cell cytokines with anhedonia: Role of gender differences

Psychoneuroendocrinology
Manish K JhaM H Trivedi

Abstract

Among individual depressive symptoms, anhedonia has been reliably associated with activation of the innate immune response. However, it is unclear whether this association extends to T cell cytokines and if gender differentially affects this association. Concentrations of T (IL-17, T-helper (Th) 1- and Th2-) and non-T cell cytokines were measured in plasma using the Bioplex Pro™ human cytokine multiplex kit in Combining Medications to Enhance Depression Outcomes (CO-MED) trial participants who provided plasma at baseline (n = 166). Anhedonia was measured with three items of the clinician-rated Inventory of Depressive Symptomatology and depression severity (minus anhedonia item) was measured with Quick Inventory of Depression Severity Self-Report version (modified-QIDS-SR). Separate generalized linear models for anhedonia and modified-QIDS-SR as dependent variables were conducted with IL-17, Th1-, Th2-, and non-T cell- cytokines as primary independent variables and gender, body mass index (BMI), and age as covariates. Exploratory analyses included gender-by-biomarker interactions. Higher levels of IL-17 (p = 0.032), Th1- (p = 0.002), Th2-(p = 0.001) and non-T-(p = 0.009) cell markers were associated with greater severity of anhe...Continue Reading

Citations

Mar 6, 2019·Stress : the International Journal on the Biology of Stress·Maximus BergerRobyn McDermott
Dec 4, 2019·The European Journal of Neuroscience·Caroline NothdurfterThomas C Baghai
Jan 8, 2022·Harvard Review of Psychiatry·David S Thylur, David R Goldsmith

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