Association of T lymphocyte immune imbalance and IL-10 gene polymorphism with the risk of obstructive sleep apnea in children with obesity

Sleep & Breathing = Schlaf & Atmung
Miao-Shang SuJi-Shan Zheng

Abstract

The purpose of this study is to determine the role of T lymphocyte immune imbalance and interleukin (IL)-10 gene polymorphism in the development of obstructive sleep apnea (OSA) in obese children. One hundred obese children at high-risk and low-risk for OSA based upon a sleep questionnaire were selected. Peripheral blood T lymphocyte subsets were measured by flow cytometry, and plasma IFN-γ, IL-4, and IL-10 cytokines were detected by ELISA. The relationships between OSA and the above variables were analyzed. IL-10 gene polymorphisms were analyzed by DNA sequencing. Ninety subjects completed all the tests. Forty-two patients were diagnosed as OSA by PSG. Compared with non-OSA children, the levels of CD4+ T cells, IFN-γ, and IL-4 were increased (P < 0.05) whereas the numbers of CD4+ CD25+ Treg and NKT cells and the levels of IL-10 were reduced (P < 0.05). Multiple linear regression analysis showed that IL-10 level was negatively associated with OAHI (OR 0.352, 95% CI 0.286-0.540; P < 0.05). In multivariate analysis, IL-10 also had a strong negative association with OSA after adjustment for confounding factors from models 1 to 3. Correlative analysis showed that IL-10 levels had a positive association with CD4+ CD25+ Treg (r = 0.6...Continue Reading

References

Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·John W SteinkeLarry Borish
May 3, 2005·The European Respiratory Journal·L DyugovskayaL Lavie
Sep 11, 2007·Sleep Medicine·David GozalLeila Kheirandish-Gozal
Feb 16, 2008·American Journal of Respiratory and Critical Care Medicine·David GozalLeila Kheirandish-Gozal
Jan 24, 2009·Immunological Reviews·David M Mosser, Xia Zhang
Jan 27, 2009·Current Protocols in Human Genetics·Stacey GabrielDiana Tabbaa
Jan 15, 2010·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Jun 14, 2012·Scandinavian Journal of Immunology·C BrennerJ Turner
Aug 23, 2012·Pediatric Pulmonology·Xiao-Hong CaiLiang-Xing Wang
Jan 25, 2013·Mediators of Inflammation·Jin YeYuan Li
Jun 6, 2014·Mediators of Inflammation·Cheryl Wang
Jun 24, 2015·Mediators of Inflammation·Joanna Domagała-KulawikTomasz Skirecki
Sep 1, 2015·European Journal of Pediatrics·Miao-Shang SuYan-Feng Xiao

❮ Previous
Next ❯

Citations

Sep 9, 2017·Sleep & Breathing = Schlaf & Atmung·Xiaoxia LuTaoping Li
Aug 27, 2021·European Journal of Clinical Investigation·Minhan YiYuan Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Kanokporn UdomittipongSuwat Tangchityongsiva
Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Zhan ZhangWanyu Song
Diagnostic Microbiology and Infectious Disease
Zhi-Jun SuZhen-Zhong Lin
© 2022 Meta ULC. All rights reserved