Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response

Genes & Development
Erin K ShanleBrian D Strahl

Abstract

The YEATS domain, found in a number of chromatin-associated proteins, has recently been shown to have the capacity to bind histone lysine acetylation. Here, we show that the YEATS domain of Taf14, a member of key transcriptional and chromatin-modifying complexes in yeast, is a selective reader of histone H3 Lys9 acetylation (H3K9ac). Structural analysis reveals that acetylated Lys9 is sandwiched in an aromatic cage formed by F62 and W81. Disruption of this binding in cells impairs gene transcription and the DNA damage response. Our findings establish a highly conserved acetyllysine reader function for the YEATS domain protein family and highlight the significance of this interaction for Taf14.

References

Dec 1, 1994·Genes & Development·N L HenryR D Kornberg
Feb 20, 1999·The Journal of Biological Chemistry·P A GrantJ L Workman
Mar 26, 2002·FEBS Letters·Lei Zeng, Ming Ming Zhou
Feb 26, 2004·Methods in Enzymology·Xuetong Shen
Apr 27, 2005·Biochemical and Biophysical Research Communications·Barbara Kowalska-LothKrzysztof Staroń
Mar 17, 2007·Annual Review of Biochemistry·Mona D Shahbazian, Michael Grunstein
Jul 17, 2007·The Journal of Biological Chemistry·Slobodan BarbaricPhilipp Korber
Feb 24, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Julia M SchulzeMichael S Kobor
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alice Y WangMichael S Kobor
Feb 25, 2010·Molecular Genetics and Genomics : MGG·Julia M SchulzeAna Ruiz-Manzano
Dec 21, 2010·Current Biology : CB·Stephen M FuchsBrian D Strahl
Feb 16, 2011·Cell Research·Andrew J Bannister, Tony Kouzarides
Aug 23, 2012·Methods in Enzymology·Scott B RothbartStephen M Fuchs
Oct 2, 2012·Nature Structural & Molecular Biology·Scott B RothbartBrian D Strahl
Dec 6, 2012·Nature Structural & Molecular Biology·Catherine A MusselmanTatiana G Kutateladze
Mar 19, 2014·Biochimica Et Biophysica Acta·Scott B Rothbart, Brian D Strahl

❮ Previous
Next ❯

Citations

Mar 5, 2016·Transcription·Forest H AndrewsTatiana G Kutateladze
Apr 19, 2016·Nature Chemical Biology·Forest H AndrewsTatiana G Kutateladze
Aug 19, 2016·Nature Chemical Biology·Forest H AndrewsTatiana G Kutateladze
Dec 8, 2016·Nature Reviews. Molecular Cell Biology·Benjamin R SabariYingming Zhao
Jan 6, 2017·Nature Reviews. Molecular Cell Biology·Colin M HammondAnja Groth
Feb 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Shigeki NagaiRoger D Kornberg
Feb 28, 2017·Nature·Michael A ErbJames E Bradner
Nov 18, 2017·Nucleic Acids Research·Brianna J KleinTatiana G Kutateladze
Sep 14, 2018·PLoS Genetics·Bram HennemanRemus T Dame
Jan 13, 2017·Microbiology and Molecular Biology Reviews : MMBR·Victoria JeffersWilliam J Sullivan
Aug 30, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jérôme PoliManolis Papamichos-Chronakis
Aug 30, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Li-Ya ChiuKyle M Miller
Nov 6, 2018·Nature Communications·Brianna J KleinTatiana G Kutateladze
Feb 12, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Kirk L WestAlan J Tackett
Dec 14, 2017·Nature Communications·Renata Z JurkowskaAlbert Jeltsch
Jan 11, 2019·Nature Communications·James E LongbothamDanica Galonić Fujimori
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huihui ZhuJingji Jin
Jul 14, 2019·Trends in Cell Biology·Tanja Bhuiyan, H Th Marc Timmers
Apr 30, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Subham BasuDebabrata Biswas
May 17, 2021·Current Opinion in Structural Biology·Kendra R VannTatiana G Kutateladze
Jul 20, 2021·Journal of Medicinal Chemistry·Xinyu R MaHong Wen
Sep 29, 2021·Omics : a Journal of Integrative Biology·Pratigya Subba, Thottethodi Subrahmanya Keshava Prasad
Dec 3, 2021·PLoS Pathogens·Krista FleckVictoria Jeffers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.