Abstract
Despite the increasing burden of type 2 diabetes (T2D) and its established association with anthropometric and physiological traits as a risk factor, genetic studies focusing on the association of T2D-related genes with quantitative traits like body mass index (BMI), waist-hip ratio (WHR), and systolic blood pressure (SBP) are only a few for western populations and rare for Indian populations. The present study tested the association of TCF7L2, HHEX, KCNJ11, and ADIPOQ with BMI, SBP, and WHR in men and women of the Aggarwal population of India and found a differential association of TCF7L2 (rs7903146, rs4506565, and rs12256372) and ADIPOQ (rs2241766 and rs1501299) genes with increasing BMI, SBP, and WHR between the two sexes. We conclude that TCF7L2 and ADIPOQ together might play an important role in explaining these traits and to understand the biological and genetic mechanisms underlying T2D, and the role of other T2D genes must also be evaluated with these continuous traits.
References
Jul 26, 2002·Molecular and Cellular Biology·Sarah E RossOrmond A MacDougald
Jan 18, 2006·Nature Genetics·Struan F A GrantKari Stefansson
Apr 29, 2006·Diabetes·Ken K OngDavid B Dunger
Aug 29, 2006·Diabetes·Cuilin ZhangFrank B Hu
Jan 9, 2007·Nature Genetics·Agnar HelgasonKári Stefánsson
Jan 25, 2007·Diabetologia·M HorikoshiT Kadowaki
Feb 13, 2007·Nature·Robert SladekPhilippe Froguel
Apr 28, 2007·Science·Laura J ScottMichael Boehnke
May 12, 2007·Epidemiologic Reviews·Gabriela VazquezKarri Silventoinen
Jul 31, 2007·Diabetologia·S A SchäferA Fritsche
Feb 2, 2008·Obesity·Stéphane CauchiPhilippe Froguel
Apr 10, 2008·Annals of Human Genetics·D K SangheraM I Kamboh
Jul 25, 2009·Diabetes Care·David R MullicanSteven M Haffner
Sep 26, 2009·Nature·David ReichLalji Singh
Dec 24, 2009·Diabetes·Axel HauptHarald Staiger
Jan 6, 2010·PloS One·Slavica PecioskaYurii S Aulchenko
Apr 29, 2010·Diabetes·Ganesh ChauhanGiriraj R Chandak
Jul 6, 2010·Annals of Human Genetics·Vipin GuptaM P Sachdeva
Citations
Aug 15, 2013·Diabetologia·Fabrice BonnetUNKNOWN DESIR and RISC Study Groups
Aug 8, 2013·Hepatitis Monthly·Mohammad HashemiSaeid Ghavami
Oct 12, 2014·Experimental Gerontology·Ge XinLiu Hui
Dec 11, 2014·BMC Genetics·Hadjira Ouhaibi-DjellouliAline Meirhaeghe
Jul 27, 2014·American Journal of Hypertension·Jacob J BassonDabeeru C Rao
Sep 29, 2018·PloS One·Harjit KaurAnupam Kaur
Jul 22, 2018·Molecular Biology Reports·Sukma OktavianthiSafarina G Malik
Sep 2, 2018·Hormones : International Journal of Endocrinology and Metabolism·Uzma ZafarKhalid P Lone
Jan 28, 2021·Nutrients·Buthaina E AlathariKarani S Vimaleswaran