Association of TET3 epigenetic inactivation with head and neck cancer

Oncotarget
Kiyoshi MisawaHiroyuki Mineta

Abstract

The aim of this study was to clarify the epigenetic regulation of ten eleven translocation protein (TET) family genes, which can provide insights into the mechanisms of tumorigenesis and the risk of disease recurrence in head and neck squamous cell carcinoma (HNSCC). We generated methylation profiles of TET1, TET2 and TET3 genes in tumor samples obtained from 233 patients with HNSCC; these included 57 hypopharynx, 44 larynx, 69 oral cavity, and 63 oropharynx tumor samples. The mRNA expression and promoter DNA methylation of TET family genes were examined via quantitative RT-PCR and methylation-specific PCR, respectively. Promoter methylation was compared with various clinical characteristics and the TET methylation index (TE-MI). The TE-MI, representing the number of methylation events in TET family genes, was positively correlated with alcohol consumption (P = 0.004), high-risk human papilloma virus (HPV) status (P = 0.004) and disease recurrence (P = 0.002). The simultaneous methylation analysis of TET family genes was correlated with reduced disease-free survival in unfavorable event groups (log-rank test, P = 0.026). In the multivariate Cox proportional hazards analysis, TET3 methylation in T1 and T2 tumor stages, oropharyn...Continue Reading

References

Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tiziana MartoneGiorgio Cortesina
May 14, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bhavna KumarThomas E Carey
May 20, 2008·Lancet·Athanassios ArgirisRobert L Ferris
Aug 13, 2008·International Journal of Cancer. Journal International Du Cancer·Eun Ju LeeDuk-Hwan Kim
Aug 30, 2008·International Journal of Cancer. Journal International Du Cancer·Zhe JinStephen J Meltzer
Apr 20, 2010·Cancer Causes & Control : CCC·Elaine M SmithLubomir P Turek
Dec 21, 2010·Experimental Hematology·Fabian MohrVijay P S Rawat
Jun 22, 2011·Journal of Clinical Pathology·Young-Ho KimHiroko Ohgaki
Jan 1, 2011·Cancer Biomarkers : Section a of Disease Markers·Kiyoshi MisawaHiroyuki Mineta
Jul 5, 2012·Cancer Research·Atsushi KanedaMasashi Fukayama
Sep 8, 2012·Advances in Experimental Medicine and Biology·Bilian Jin, Keith D Robertson
Feb 20, 2013·Journal of Cancer Research and Clinical Oncology·Kiyoshi MisawaHiroyuki Mineta
Oct 31, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Pauline M W van KempenWilko Grolman
Nov 21, 2013·Cancer Biology & Therapy·Chao Ye, Lan Li
Mar 14, 2014·Protein & Cell·David M RoyTimothy A Chan
Mar 25, 2014·Oral Oncology·L M R B ArantesE M Goloni-Bertollo
May 14, 2014·Frontiers in Oncology·Dharmalingam SubramaniamShrikant Anant
Aug 8, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Chunping DuHaruhiko Sugimura
Aug 19, 2014·Trends in Genetics : TIG·Yun Huang, Anjana Rao
Nov 16, 2014·Nucleic Acids Research·Wei-Yun HuangHsien-Da Huang
Jan 30, 2015·Nature·UNKNOWN Cancer Genome Atlas Network
Jun 13, 2015·Cancer Prevention Research·Norihisa IchimuraYutaka Kondo
Oct 27, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gloria RavegniniSabrina Angelini
Apr 3, 2016·Genes & Development·Kasper Dindler Rasmussen, Kristian Helin
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Piotr CiesielskiAnna Krześlak
Jun 16, 2017·Clinical Epigenetics·Kiyoshi MisawaTakeharu Kanazawa

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Citations

Jan 8, 2019·Journal of Dental Research·M V Bais
Sep 14, 2019·Cancers·Matthias OckerRegine Schneider-Stock
Jan 24, 2020·Journal of Translational Medicine·Kiyoshi MisawaHiroyuki Mineta
Nov 25, 2018·International Journal of Molecular Sciences·Daiki MochizukiKiyoshi Misawa
Feb 2, 2021·Frontiers in Cell and Developmental Biology·Spyridon GougousisIoannis Constantinidis
Jul 25, 2021·Cancers·Francisco D Rodriguez, Rafael Coveñas

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Stata
StatMate IV
SE
Thermal Cycler Dice Real Time System TP800

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