Association of textile industry effluent with mutagenicity and its toxic health implications upon acute and sub-chronic exposure

Environmental Monitoring and Assessment
Muhammad Furqan AkhtarBushra Akhtar

Abstract

Complex industrial discharges pose certain risks to the ecosystem. This study was aimed at identifying acute and sub-chronic toxicological effects of the textile industry wastewater. The textile wastewater was evaluated for the metals and organic pollutants by atomic absorption spectrophotometer and GC-MS respectively. In vitro genotoxicity and mutagenicity were assessed by Comet assay in peripheral lymphocytes isolated from Ovis aries and Ames test in Salmonella typhimurium strains TA-100 and 102 respectively. Physiological and behavioral changes along with systemic toxicity were determined in Rattus norvegicus albinus following acute and sub-chronic exposure. High amount of heavy metals such as Cr, Pb, Hg, As, and Cd were detected in textile wastewater. Organic pollutants such as 25-deacetoxy cucurbitacin-b, E-14-Hexadecenal, 11-Tricosene, and phthalates were also found. In vitro genotoxicity assessment in lymphocytes showed statistically significant DNA damaging potential of textile wastewater. Textile wastewater also showed significantly higher (p˂ 0.05) mutagenic potential in Salmonella TA-100 and TA-102 strains than sodium azide and 2-amino anthracycline. Acute exposure of textile wastewater to Rattus norvegicus was assoc...Continue Reading

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Citations

Jan 16, 2019·Medicina·Mubin Mustafa KiyaniSyed Ali Imran Bokhari
Jul 31, 2020·Journal of Food Biochemistry·Ammara SaleemAzhar Rasul
Nov 24, 2020·Environmental Toxicology and Pharmacology·Nosra MethneniHedi Ben Mansour

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