Association of TGFβ1 and clinical factors with scar outcome following melanoma excision

Archives of Dermatological Research
Sarah V WardL J Palmer

Abstract

All patients with primary cutaneous malignant melanoma undergo surgical excision to remove the tumour, resulting in scar formation. There is marked variation in the aesthetic appearance of scars following surgery but limited knowledge about the genetic factors affecting non-keloid, surgical scar outcomes. This study aimed to investigate the role of known clinical factors and genetic polymorphisms in pigmentation and wound repair genes in non-keloid scar outcome, following melanoma excision. Participants were 202 cases who underwent a standardized scar assessment following surgical melanoma excision and provided a DNA sample. Genetic association analyses between single nucleotide polymorphisms (SNPs) from 24 candidate genes and scar outcome data were performed, controlling for relevant clinical factors. Following adjustment for multiple testing, SNP rs8110090 in TGFβ1 was significantly associated with both the primary scar outcome (a combination score reflecting vascularity, height and pliability, p = 0.0002, q = 0.01) and the secondary scar outcome (a combination score reflecting vascularity, height, pliability and pigmentation, p = 0.0002, q = 0.006). The minor allele G was associated with a poorer scar outcome. Younger age, t...Continue Reading

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Aug 14, 2012·Archives of Dermatological Research·Chenyu HuangRei Ogawa
Nov 6, 2012·Cellular Signalling·Maulilio John KipanyulaArmel Hervé Nwabo Kamdje
Dec 17, 2014·Expert Review of Anticancer Therapy·Khan ShahanavajChristian Rolfo

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