Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Monika JohannNorbert Wodarz

Abstract

Several lines of evidence indicate an involvement of the dopaminergic system in alcoholism, withdrawal, suicidality, and attention-deficit hyperactivity disorder (ADHD). The functionally relevant -141C Ins/Del polymorphism located upstream to exon 1 in the 5'-region of the dopamine D2 receptor (DRD2) gene might be an interesting candidate gene. We investigated a sample of 1,126 well-characterized, primary chronic alcoholics of German descent according to a phenotype-genotype strategy, i.e., alcoholics suffering from severe withdrawal complications such as seizure or delirium, family history positive (FH+) alcoholics, alcoholics with an antisocial personality disorder (ASPD), alcoholics with an ADHD, and type 1 or type 2 alcoholics according to Cloninger's typology. Compared to the control subjects, there was a significant excess of the -141C Del allele in alcoholics with a paternal and grandpaternal history of alcoholism and in alcoholic subgroups with suicidality or without a history of withdrawal symptoms. There were no significant differences in allele frequency between the entire group or subgroups of alcoholics and healthy controls. Therefore, the -141C Del variant of the DRD2 might be a protective factor against the devel...Continue Reading

References

Jun 15, 1992·Biological Psychiatry·W PitchotM Ansseau
May 1, 1992·Trends in Pharmacological Sciences·G F Koob
Apr 1, 1990·Archives of General Psychiatry·G E Murphy, R D Wetzel
Apr 24, 1987·Science·C R Cloninger
Nov 1, 1985·Archives of General Psychiatry·M A Schuckit
Sep 1, 1996·Journal of Studies on Alcohol·A HeinzH Rommelspacher
May 15, 1997·Biological Psychiatry·B ArranzJ Marcusson
Nov 28, 1997·Brain Research·C BowdenR W Horton
Jul 11, 1998·Alcoholism, Clinical and Experimental Research·H IshiguroH Shibuya
Oct 16, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·G EngströmL Träskman-Bendz
Jan 20, 2000·Psychopharmacology·E RepoJ Tiihonen
Jul 6, 2000·European Psychiatry : the Journal of the Association of European Psychiatrists·E P Noble
Jul 18, 2000·American Journal of Medical Genetics·A ParsianZ H Zhang
Oct 31, 2000·American Journal of Medical Genetics·O BlomqvistH R Kranzler
Sep 13, 2001·Journal of Neurochemistry·P K ThanosR Hitzemann
Dec 1, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·W PitchotM Ansseau
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ernest P Noble
Jun 27, 2003·Synapse·Isabelle BoileauAlain Dagher

❮ Previous
Next ❯

Citations

Feb 28, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Huidrom Suraj SinghKallur Nava Saraswathy
Apr 6, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·So Hee LeeIhn Geun Choi
Sep 12, 2006·Addiction Biology·Richard L BellWilliam J McBride
Jun 25, 2014·Indian Journal of Human Genetics·Niladri Banerjee
Oct 28, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shih-Jen TsaiYing-Jay Liou
Apr 16, 2010·European Psychiatry : the Journal of the Association of European Psychiatrists·D Rujescu, I Giegling
Apr 29, 2008·The Psychiatric Clinics of North America·Jelena BrezoGustavo Turecki
Apr 29, 2008·The Psychiatric Clinics of North America·Dianne Currier, J John Mann
Jan 26, 2007·Alcoholism, Clinical and Experimental Research·Barbara C van MunsterAeilko H Zwinderman
Apr 28, 2010·Behavioral Sciences & the Law·Tracy D GunterRobert A Philibert
Aug 22, 2006·Trends in Pharmacological Sciences·K Yaragudri Vinod, Basalingappa L Hungund
Apr 24, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shoko TsuchimineSunao Kaneko
Sep 3, 2014·Molecular Psychiatry·M SokolowskiD Wasserman
Sep 19, 2006·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Anne S HinckersManfred Laucht
Feb 8, 2006·Molecular Psychiatry·B BondyP Zill
Dec 21, 2006·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Dan RujescuIna Giegling
Feb 17, 2009·International Review of Psychiatry·Dimitrios AdamisAlastair J D Macdonald
Jun 23, 2020·Annals of General Psychiatry·Anna MichalczykJerzy Samochowiec

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.