Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival.

BJU International
Erin R GardnerWilliam D Figg

Abstract

To determine if the C421A single nucleotide polymorphism (SNP) in the ATP-binding cassette transporter ABCG2 increases prostate cancer risk or affects survival. Numerous studies have suggested that dietary, hormonal and environmental factors all play a role in the initiation in prostate cancer; among these, the carcinogenic heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a known substrate of the ABCG2. A SNP of ABCG2, C421A, resulting in a glutamine to lysine change at amino acid 141, has been shown to result in decreased function of the protein. Due to the expression of ABCG2 in the prostate, together with the purported role of dietary carcinogens and steroids in the development and progression of prostate cancer, 311 individuals were genotyped for the ABCG2 C421A SNP, 170 patients with androgen-independent prostate cancer (AIPC) and 141 'healthy' controls. We also evaluated the effect of this SNP on the intracellular accumulation of PhIP and testosterone in vitro. There were no significant differences in the prevalence of prostate cancer based on ABCG2 genetic variation in this population. However, survival was significantly longer for individuals with wild-type ABCG2, as compared with those hetero-...Continue Reading

References

Jul 31, 2001·Journal of Exposure Analysis and Environmental Epidemiology·K T Bogen, G A Keating
Jul 12, 2002·The Prostate·Ann W HsingFrank Z Stanczyk
Apr 2, 2003·The Journal of Biological Chemistry·Tavan JanvilisriHendrik W van Veen
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Shinji MizuaraiHidehito Kotani
Mar 6, 2004·The Journal of Biological Chemistry·Junkang XuJian-Ting Zhang
Jul 2, 2004·Clinical Pharmacology and Therapeutics·Alex SparreboomHoward L McLeod
Sep 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Floris A de JongHoward L McLeod
Nov 24, 2004·Pharmaceutical Research·Chihiro KondoYuichi Sugiyama
Apr 20, 2005·Cancer Chemotherapy and Pharmacology·Kuniaki MorisakiSusan E Bates
Jul 2, 2005·Cancer Letters·Patricia A FetschSusan E Bates
Sep 6, 2005·Cancer Research·Rashmi SinhaRichard B Hayes
Dec 17, 2005·Cancer Research·Amanda J CrossRashmi Sinha
Aug 8, 2006·Clinical Pharmacology and Therapeutics·Erin R GardnerKees Nooter
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Noah M HahnChristopher J Sweeney
Feb 27, 2007·Cancer Metastasis Reviews·Robert W RobeySusan E Bates
Apr 12, 2007·BMC Urology·Laura E PascalAlvin Y Liu
Dec 21, 2007·Molecular Pharmacology·Saroj VelamakanniHendrik W van Veen

❮ Previous
Next ❯

Citations

Nov 3, 2012·Therapeutic Advances in Medical Oncology·Clara Hwang
Apr 30, 2014·Archives of Toxicology·Márton JaniPéter Krajcsi
Sep 16, 2011·International Journal of Cancer. Journal International Du Cancer·Daniele CampaAlexandra Nieters
Jan 17, 2015·Journal of Experimental & Clinical Cancer Research : CR·Karolina TeczaEwa Grzybowska
Nov 19, 2015·Journal of Applied Genetics·Aleksandra Salagacka-KubiakEwa Balcerczak
Jul 6, 2013·Neuroscience Letters·Ágnes FehérZoltán Janka
Apr 20, 2014·Molecular Pharmaceutics·Feng Li, Ram I Mahato

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.