Association of the angiotensinogen M235T and angiotensin-converting enzyme insertion/deletion gene polymorphisms in Turkish type 2 diabetic patients with and without nephropathy

Journal of Diabetes and Its Complications
Zuhal ErogluM Tuzun

Abstract

Recent studies have suggested an association between a deletion variant of the angiotensin-converting enzyme (ACE) gene and diabetic nephropathy. However, this finding has not been confirmed by all investigators. Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy. We investigated the relationship of the ACE insertion/deletion (I/D) and AGT M235T gene polymorphisms in Turkish patients with type 2 diabetes mellitus (DM) with and without diabetic nephropathy. A total of 102 individuals were screened for the presence of the ACE I/D and AGT M235T polymorphism: 46 individuals who had type 2 DM with diabetic nephropathy and, as controls, 56 individuals who had type 2 DM without diabetic nephropathy. Gene polymorphisms were determined by the specific melting temperature (T(m)) values of the resulting amplicons after real-time online polymerase chain reaction and melting curve analysis. The frequencies of the ACE DD, ID, and II genotypes were 34.8%, 37.0%, and 28.3%, respectively, among type 2 diabetic patients with nephropathy, and 33.9%, 42.9%, 23.2%, respectively (P=.788), in the control subjects wi...Continue Reading

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Citations

Oct 30, 2010·Indian Journal of Human Genetics·Jaime J JayapalanSiew P Chan
Oct 1, 2012·Journal of Nephropathology·Zohreh Rahimi
Dec 2, 2015·Canadian Journal of Diabetes·Zohreh Rahimi
Oct 29, 2014·Renal Failure·Song Mao, Songming Huang
Oct 9, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Ahmad AliAhmad Settin
Mar 23, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Nabil MtiraouiWassim Y Almawi
Jul 16, 2008·Molecular Biology Reports·Kimberly L GlennMax F Rothschild
May 5, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Rizk El-BazMohammed Abd El-Kader Sobh

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