Association of the blood eosinophil count with end-organ symptoms

Annals of Medicine and Surgery
Ole Weis BjerrumChristen Lykkegaard Andersen

Abstract

Eosinophilia may cause organ dysfunction, but an exact relation between eosinophil blood counts and adverse outcomes has not been described. The aim of the study is to associate in one model both normal and increased blood eosinophil counts to the subsequent development of common conditions in internal medicine, in which eosinophil granulocytes may play a role for the symptoms. From the Copenhagen Primary Care Differential Count (CopDiff) Database, we identified 359,950 individuals with at least one differential cell count (DIFF) during 2000-2007. From these, one DIFF was randomly chosen. From the Danish National Patient Register we ascertained organ damage, within four years following the DIFF. Using multivariable logistic regression, odds ratios were calculated and adjusted for previous eosinophilia, sex, age, year, month, CRP and comorbid conditions. Risks for skin- and respiratory disease were increased from above the median eosinophil count of 0.16 × 109/l and reached a plateau around 1.0 × 109/l. Furthermore, risks of most outcomes also increased when the eosinophil count approached zero. The observed U-shaped association with a plateau of risks around 1 × 109/l indicates that the risk for symptoms due to eosinophilia do ...Continue Reading

References

Jan 1, 1989·European Neurology·I LupoR M Camarda
Jan 1, 1985·Annals of Internal Medicine·P M MooreA S Fauci
Jan 1, 1988·Clinical Neurology and Neurosurgery·J J PrickT W van der Wiel
Apr 1, 1985·The American Journal of Medicine·J S WeingartenW S Margolis
Jul 1, 1982·The American Journal of Medicine·J B HarleyA S Fauci
May 1, 1982·Clinical and Experimental Dermatology·H M van den Hoogenband
Nov 1, 1994·American Journal of Respiratory and Critical Care Medicine·J N Allen, W B Davis
Nov 1, 1993·Angiology·P V FeliceJ Anto
Jan 1, 1997·American Journal of Clinical Pathology·H ParryM J Jarvis
Mar 20, 1997·The New England Journal of Medicine·M B SalzmanS K Sood
Apr 21, 1999·Deutsche medizinische Wochenschrift·B BalestraF Regli
Jan 26, 2000·Postgraduate Medical Journal·F Díaz, J Collazos
Jun 8, 2002·Annals of Biomedical Engineering·Scott I Simon, Harry L Goldsmith
Apr 16, 2003·British Journal of Haematology·Finella Brito-Babapulle
Sep 17, 2003·Apoptosis : an International Journal on Programmed Cell Death·A DruilheM Pretolani
Feb 8, 2006·Clinical Reviews in Allergy & Immunology·Delphine Staumont-SalléEmmanuel Delaporte
May 10, 2006·British Journal of Haematology·Ayalew TefferiAnimesh Pardanani
Jul 11, 2006·Lancet·K A BrownD F Treacher
Apr 4, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Simon P HoganMarc E Rothenberg
Apr 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alessandra CarobbioTiziano Barbui
May 1, 2008·International Archives of Allergy and Immunology·Ugur Gonlugur, Tanseli Efeoglu Gonlugur
Feb 24, 2009·Advances in Immunology·Carine Blanchard, Marc E Rothenberg
Mar 25, 2010·Human & Experimental Toxicology·Edward J Calabrese
May 8, 2010·International Journal of Toxicology·Eric L KendigScott M Belcher
Aug 6, 2010·Journal of Physiological Anthropology·Katsuyasu Kouda, Masayuki Iki
Jan 21, 2011·Clinical Reviews in Allergy & Immunology·Fu-Tong LiuHuan-Yuan Chen
Aug 4, 2011·Scandinavian Journal of Public Health·Elsebeth LyngeMatejka Rebolj
Aug 4, 2011·Scandinavian Journal of Public Health·Marianne Lundkjær Gjerstorff
Aug 25, 2011·Current Rheumatology Reports·Andy Abril
Mar 14, 2012·The Journal of Allergy and Clinical Immunology·Stanley J SzeflerMichael Minnicozzi
Jun 8, 2013·Allergy·G J GleichP F Weller

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.