PMID: 9171954Jun 1, 1997Paper

Association of the brain natriuretic peptide gene with blood pressure and heart weight in the rat

Clinical and Experimental Pharmacology & Physiology
L ZhangK M Summers

Abstract

1. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are important in the control of body fluid homeostasis, blood pressure (BP) regulation and vascular remodelling. The genes for these peptides may, therefore, be involved in the pathogenesis of genetic hypertension. We have previously described a quantitative trait locus (QTL) for BP in the ANP gene region on rat chromosome 5. We have now assessed the possibility that this QTL lies at the closely linked BNP locus. 2. Intra-arterial BP and heart weight were measured in 12-week-old (n = 207) and 24-week-old (n = 88) F2 rats derived from crosses between Wistar-Kyoto normotensive rats and spontaneously hypertensive rats. We designed polymerase chain reaction primers to amplify a microsatellite in the BNP gene from genomic DNA. Analysis of variance was used for cosegregation analysis. Linkage mapping and localization of QTL was performed using the Mapmaker computer package. 3. A significant correlation was found between genotype for the BNP gene and systolic BP (P < 0.001) in 12-week-old rats. The ANP gene, but not the BNP gene, was associated with systolic BP in 24 week rats. There was no segregation of heart weight with BNP genotype at 12 or 24 weeks of age. Th...Continue Reading

References

Aug 31, 1990·Biochemical and Biophysical Research Communications·R N Roy, T G Flynn
May 20, 1988·European Journal of Pharmacology·H ItohH Imura
Jun 1, 1996·Clinical and Experimental Pharmacology & Physiology·L ZhangM J West
Nov 1, 1996·Clinical and Experimental Hypertension : CHE·L ZhangM J West

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