Association of the CpG methylation pattern of the proximal insulin gene promoter with type 1 diabetes.

PloS One
Delphine FradinPierre Bougnères

Abstract

The insulin (INS) region is the second most important locus associated with Type 1 Diabetes (T1D). The study of the DNA methylation pattern of the 7 CpGs proximal to the TSS in the INS gene promoter revealed that T1D patients have a lower level of methylation of CpG -19, -135 and -234 (p = 2.10(-16)) and a higher methylation of CpG -180 than controls, while methylation was comparable for CpG -69, -102, -206. The magnitude of the hypomethylation relative to a control population was 8-15% of the corresponding levels in controls and was correlated in CpGs -19 and -135 (r = 0.77) and CpG -135 and -234 (r = 0.65). 70/485 (14%) of T1D patients had a simultaneous decrease in methylation of CpG -19, -135, -234 versus none in 317 controls. CpG methylation did not correlate with glycated hemoglobin or with T1D duration. The methylation of CpG -69, -102, -180, -206, but not CpG -19, -135, -234 was strongly influenced by the cis-genotype at rs689, a SNP known to show a strong association with T1D. We hypothesize that part of this genetic association could in fact be mediated at the statistical and functional level by the underlying changes in neighboring CpG methylation. Our observation of a CpG-specific, locus-specific methylation pattern...Continue Reading

Associated Clinical Trials

Jul 8, 2015·Assimina Galli-Tsinopoulou

References

Apr 1, 1995·Human Molecular Genetics·A M LucassenJ I Bell
Jan 1, 1996·Annual Review of Genetics·S T Bennett, J A Todd
Mar 15, 2003·Science·Hengmi CuiAndrew P Feinberg
Sep 28, 2005·Diabetes·Patrick ConcannonUNKNOWN Type 1 Diabetes Genetics Consortium
Oct 31, 2006·Nature Genetics·Florian EckhardtStephan Beck
Jul 17, 2007·Nature·Hakon HakonarsonConstantin Polychronakos
Sep 15, 2007·Nature Protocols·Jörg Tost, Ivo G Gut
Mar 5, 2008·Genome Research·Rafael A IrizarryAndrew P Feinberg
Dec 17, 2008·The Journal of Experimental Medicine·Pierre Bougnères, Alain-Jacques Valleron
Mar 25, 2009·Nature Reviews. Genetics·Howard Cedar, Yehudit Bergman
May 12, 2009·Nature Genetics·Jeffrey C BarrettUNKNOWN Type 1 Diabetes Genetics Consortium
Sep 11, 2009·PloS One·Akio KurodaKevin Ferreri
Dec 5, 2009·Genome Biology·Yingying ZhangAlbert Jeltsch
Apr 24, 2010·Immunity·John A Todd
May 25, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Salah AzziIrène Netchine
Aug 19, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Emma L MeaburnJonathan Mill
Aug 16, 2011·Genomics·Marina BibikovaRichard Shen
Nov 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eitan M AkiravKevan C Herold

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Citations

Apr 23, 2014·Clinical Reviews in Allergy & Immunology·Zhiguo XieZhiguang Zhou
Sep 24, 2014·Trends in Endocrinology and Metabolism : TEM·Dario F De Jesus, Rohit N Kulkarni
Aug 2, 2013·International Journal of Biological Sciences·Yan-Ling WuWen Zhang
Oct 9, 2012·Current Opinion in Gastroenterology·Andreas C Jenke, Matthias Zilbauer
Jan 29, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bao SunWei Zhang
Jan 14, 2016·Critical Reviews in Clinical Laboratory Sciences·Laila C SchenkelBekim Sadikovic
Jan 13, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Antonietta PicasciaClaudio Napoli
Jan 11, 2016·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Zivanit ErgazAsher Ornoy
Jan 31, 2013·Annals of the New York Academy of Sciences·Natalie Nokoff, Marian Rewers
Nov 28, 2012·Diabetes/metabolism Research and Reviews·Mary Ngoc DangPaolo Pozzilli
Jan 15, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Clara Serra-JuhéLuis A Pérez-Jurado
Apr 8, 2016·Gene Therapy·C A GiménezF Pereyra-Bonnet
Jul 28, 2015·Journal of Internal Medicine·Lifeng WangM Eric Gershwin
May 17, 2013·Seminars in Hematology·Huiyuan LiRenchi Yang
Nov 12, 2013·Journal of Autoimmunity·Mihaela StefanYaron Tomer
Mar 20, 2015·Clinical Epigenetics·Meriem OuniPierre Bougnères
Jan 8, 2015·Frontiers in Genetics·Theresa Mau, Raymond Yung
Jul 23, 2013·PloS One·Marie-Pierre BelotPierre Bougnères
Nov 24, 2016·Clinical Reviews in Allergy & Immunology·Zhen WangZhiguang Zhou
Dec 21, 2017·Intractable & Rare Diseases Research·Ambreen AsimSonal Bakshi
Mar 6, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Sara M AhmedNagwa El-Badri
Dec 22, 2019·International Journal of Molecular Sciences·Marie Cerna
Aug 21, 2020·Bioscience Reports·Rajveer SinghDipanjan Ghosh
May 14, 2016·Pediatric Diabetes·Marie-Pierre BelotDelphine Fradin
Oct 4, 2018·Current Diabetes Reports·Haichen Zhang, Toni I Pollin
Sep 27, 2019·Frontiers in Endocrinology·Susanna EspositoNicola Principi
May 2, 2018·Clinical Epigenetics·Catherine Le StunffPierre Bougnères
Feb 16, 2021·Frontiers in Nutrition·Amira KohilAnnalisa Terranegra
Mar 24, 2021·Immunogenetics·Rathika ChinniahBalakrishnan Karuppiah
Apr 5, 2021·Chinese Medical Journal·Jing ZhangCong-Yi Wang

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Software Mentioned

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