PMID: 11916172Mar 28, 2002Paper

Association of the CTLA4 3' untranslated region polymorphism with the susceptibility to rheumatoid arthritis

Human Immunology
M R RodríguezMaria Francisca González-Escribano

Abstract

Cytotoxic T-lymphocyte antigen 4 (CTLA4) gene polymorphism located in the 3' untranslated region (UTR) was investigated in 141 Spanish patients (38 men and 103 women) with rheumatoid arthritis (RA) and in 194 ethnically-matched healthy controls. Twenty alleles having different numbers of (AT) repeats (from 7 to 32) were found in this population. (AT)7 and (AT)16 were the most frequent alleles, and accounted for almost two-thirds of the allelic frequency in the control population. Consequently, alleles were assigned as L (large: 16 or more AT repeats) or S (short: less than 16 AT repeats). When the L/S distribution in patients and controls were compared, an increase of L alleles was observed among patients (49.9% vs. 39.7%; p = 0.02; p(c) = 0.04, odds ratio [OR] = 1.46; 95% confidence interval [CI], 1.06-2.01). Hence, the frequency of S alleles was decreased among patients (51.1% vs. 60.3%; p = 0.02; p(c) = 0.04; OR = 0.69; 95%CI, 0.50-0.95). Moreover, a statistically significant decrease in the frequency of S/S individuals was observed among RA patients (27.7% versus 40.7%; p = 0.01; p(c) = 0.03; OR = 0.56; 95%CI, 0.34-0.91). These differences were irrespective of the HLA "shared epitope" (SE) status, and were observed similarl...Continue Reading

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Citations

Jul 19, 2005·Human Genetics·Alexandra ZhernakovaBobby P C Koeleman
Mar 17, 2010·Clinical Oral Investigations·Matthias FolwacznyHelga-Paula Török
Apr 27, 2013·Human Immunology·Naveen Chandra SuryadevaraM P J S Anandaraj
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Jul 9, 2020·Rheumatology·Laura E Dedmon

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