Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy

Diabetes
Keith L KeeneMichèle M Sale

Abstract

Variants in the ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) gene have shown positive associations with diabetes and related phenotypes, including insulin resistance, metabolic syndrome, and type 1 diabetic nephropathy. Additionally, evidence for linkage for type 2 diabetes in African Americans was observed at 6q24-27, with the proximal edge of the peak encompassing the ENPP1 gene. Our objective was to comprehensively evaluate variants in ENPP1 for association with type 2 diabetic end-stage renal disease (ESRD). Forty-nine single nucleotide polymorphisms (SNPs) located in the coding and flanking regions of ENPP1 were genotyped in 577 African-American individuals with type 2 diabetic ESRD and 596 African-American control subjects. Haplotypic association and genotypic association for the dominant, additive, and recessive models were tested by calculating a chi(2) statistic and corresponding P value. Nine SNPs showed nominal evidence for association (P < 0.05) with type 2 diabetic ESRD in one or more genotypic model. The most significant associations were observed with rs7754586 (P = 0.003 dominant model, P = 0.0005 additive, and P = 0.007 recessive), located in the 3' untranslated region, and an intron 24 SNP (rs197...Continue Reading

References

May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Kazuyuki HamaguchiToshiie Sakata
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Feb 16, 2005·Genetic Epidemiology·Hua TangNeil J Risch
Mar 29, 2005·Diabetes·Nicola AbateViswanathan Mohan
Oct 19, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N MatsuokaW K Chung
Oct 26, 2005·Nature Genetics·Paul I W de BakkerDavid Altshuler
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Dec 22, 2005·Journal of Bone and Mineral Metabolism·Chikahiko NumakuraYukihiro Hasegawa
Sep 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Yvonne BöttcherPeter Kovacs
Nov 30, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ivan TasicVladisav Stefanovic
May 12, 2007·Journal of Diabetes and Its Complications·Manisha ChandaliaNicola Abate

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Citations

Aug 7, 2009·Metabolic Syndrome and Related Disorders·Sinan TanyolaçIra D Goldfine
Jul 2, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Barry I FreedmanDonald W Bowden
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Meredith A BostromDonald W Bowden
Jun 27, 2008·American Journal of Nephrology·Pamela J HicksBarry I Freedman
Jun 5, 2010·American Journal of Nephrology·Barry I FreedmanUNKNOWN PROFILE Study Group
Nov 8, 2015·Diabetes Research and Clinical Practice·Itahisa Marcelino-RodríguezAntonio Cabrera de León
Mar 1, 2012·Journal of Molecular and Cellular Cardiology·Nancy CôtéPatrick Mathieu
Oct 28, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Salvatore De CosmoVincenzo Trischitta
May 21, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Jun MaBarry I Freedman
Jan 11, 2012·Arquivos brasileiros de endocrinologia e metabologia·Denise Alves SorticaLuis Henrique Canani

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