Association of the G994T and R92H genotypes of platelet-activating factor acetylhydrolase with risk of preeclampsia in Chinese women

Pregnancy Hypertension
Mi ZhouPing Fan

Abstract

To investigate the relationship between platelet-activating factor acetylhydrolase (PAF-AH) gene (PLA2G7) G994T (V279F, rs76863441) and R92H (rs1805017) polymorphisms and risk of preeclampsia (PE) in Chinese women. This is a case-control study of 273 patients with PE and 530 healthy pregnant women. PLA2G7 genotypes were determined by polymerase chain reaction amplification and restriction analysis. Plasma PAF-AH, apolipoprotein (apo) B-containing lipoprotein-associated PAF-AH (apoB-PAF-AH), total high-density lipoprotein (HDL)-associated PAF-AH (H-PAF-AH), apoE-containing HDL-associated PAF-AH (apoE-H-PAF-AH) activities, and clinical, metabolic, and oxidative stress parameters were also analyzed. The frequencies of the GT + TT genotype (14.7 versus 9.2%, P = 0.019) and T allele (7.5% versus 4.6%) of PLA2G7 G994T polymorphism were significantly higher in patients with PE than in the control subjects. The GT + TT genotypes remained a significant predictor for PE in a regression model including age, body mass index (BMI), plasma PAF-AH, H-PAF-AH, apoE-H-PAF-AH and apoB-PAF-AH activities as covariates (odds ratio (OR) = 4.926, 95% confidence interval (CI): 1.707-14.219, P = 0.003). The ratio of apoB-PAF-AH to H-PAF-AH activities wa...Continue Reading

References

Aug 31, 2000·Annual Review of Biochemistry·S M PrescottT M McIntyre
Oct 18, 2000·American Journal of Obstetrics and Gynecology·B L RowlandW E Roudebush
Apr 3, 2004·Journal of Lipid Research·Mohamad NavabAlan M Fogelman
Oct 19, 2005·Hypertension·Chun LamS Ananth Karumanchi
Jan 28, 2006·Atherosclerosis·P T E WoottonP J Talmud
Jan 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Keisuke OkamuraKeijiro Saku
May 6, 2010·PLoS Genetics·Sunil SuchindranJeanette J McCarthy
Jul 6, 2010·Lancet·Eric A P SteegersRobert Pijnenborg
Jun 6, 2012·Journal of Lipid Research·Robert S Rosenson, Diana M Stafforini
Jun 12, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Hong-Wei LiuYing Wang
Aug 7, 2013·Cardiovascular Diabetology·Jose Luis Sánchez-QuesadaAntonio Pérez
Aug 10, 2013·Human Reproduction Update·A J BuurmaH J Baelde
Jul 6, 2014·American Journal of Epidemiology·Cassandra N SpracklenKelli K Ryckman
Dec 21, 2014·Archives of Gynecology and Obstetrics·Özlem Balcı EkmekçiHüseyin Sönmez
Oct 22, 2015·International Journal of Immunopathology and Pharmacology·Krzysztof Pałgan, Zbigniew Bartuzi
Feb 6, 2016·Clinical Science·Ashlyn C HarmonBabbette LaMarca
Mar 7, 2017·Thrombosis Research·Chris Gardiner, Manu Vatish
May 16, 2017·Pregnancy Hypertension·Rachel D WilliamsonLouise C Kenny
Sep 30, 2017·Journal of Biochemical and Molecular Toxicology·Jing NiKe Wang

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