PMID: 15227729Jul 1, 2004Paper

Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population

Yonsei Medical Journal
Sungha ParkYangsoo Jang

Abstract

Platelet membrane receptor glycoproteins (GP) are essential for the platelet activation process, and the genetic polymorphisms in the genes that encode platelet glycoproteins have been proposed to influence the risk of acute coronary syndrome and atherosclerosis. In this study, we investigated the role of GPIa, HPA-1 and HPA-3 polymorphisms as putative risk factors for myocardial infarction (MI) and the extent of coronary artery disease. We selected 1,073 subjects who underwent coronary angiography; 242 had normal or minimal coronary atherosclerosis, and 831 patients had significant coronary artery disease (CAD). The genotype was determined by the methods of single base extension for C807T/G873A polymorphisms of GPIa, and restriction fragment length polymorphism for HPA-1 and HPA-3. The C807T and G873A polymorphisms of GPIa showed complete linkage in the Korean population. For HPA-1 gene polymorphism, only the HPA-1a/a (PlA1/A1) genotype was observed in 192 selected subjects from our study population. The distribution of GPIa (C807T/G873A) and HPA-3 genotypes did not differ significantly between normal subjects and CAD subjects. No significant association between MI and both gene polymorphisms was present. However, for the subg...Continue Reading

Citations

Jan 29, 2008·Expert Opinion on Pharmacotherapy·Cornelia Remmler, Ingolf Cascorbi
Mar 4, 2014·Angiology·Monica VerdoiaUNKNOWN Novara Atherosclerosis Study Group (NAS)
Jan 14, 2020·Pakistan Journal of Biological Sciences : PJBS·Lamyaa Ali Elsidege Ali, Fathalrahman Mahdi Hassan
Dec 11, 2007·Transfusion Medicine·A S SabbaghR A R Mahfouz
Feb 16, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Monica VerdoiaUNKNOWN Novara Atherosclerosis Study Group (NAS)
Mar 31, 2016·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Nasrin BargahiAhmad Poursadegh Zonouzi
Jun 30, 2009·Journal of Thrombosis and Thrombolysis·Nesrine AbboudTouhami Mahjoub
Dec 2, 2009·Korean Circulation Journal·Sang-Hak LeeYangsoo Jang
Feb 1, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Monica VerdoiaGiuseppe De Luca
Nov 29, 2013·Platelets·Monica VerdoiaUNKNOWN Novara Atherosreclerosis Study Group (NAS)
Jun 12, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Nesrine AbboudTouhami Mahjoub
Jun 16, 2010·Pharmacology & Therapeutics·Dimitris TousoulisChristodoulos Stefanadis

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