Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer

Genetics and Molecular Research : GMR
L P ChenH B Liang

Abstract

Nuclear factor-κB (NF-κB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-κB gene family) is associated with increased risk of various cancers. However, only one study has reported that rs28362491 is significantly associated with ovarian cancer. The aim of this study was to analyze the association between single nucleotide polymorphisms (SNPs) and haplotypes in the NFKB1 gene and the risk of ovarian cancer in a Chinese population. We examined the potential association between ovarian cancer and 15 SNPs (rs28362491, rs3774932, rs1598856, rs230531, rs230530, rs230528, rs230521, rs230498, rs230539, rs1005819, rs3774956, rs4648055, rs4648068, rs3774964, rs3774968) of the NFKB1 gene using the MassARRAY system. Participants included 411 patients with ovarian cancer and 438 healthy controls. The results showed that the allelic or genotypic frequencies of three polymorphisms, including rs28362491 (promoter region), rs230521 (intron 4), and rs4648068 (intron 12), in the patients with ovarian cancer, were significantly different from those in the healthy...Continue Reading

Citations

Nov 14, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jiaoyang YinYegang Ma
Apr 22, 2017·Endocrine-related Cancer·Theo S PlantingaCarmen E Georgescu
Jul 19, 2018·Genetic Testing and Molecular Biomarkers·Jiashuo ChaoYan Deng
Jun 9, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Ying Jin
Mar 12, 2020·Current Drug Metabolism·Jyothsna KancharlaAfroz Alam
Sep 28, 2017·Journal of Pain and Symptom Management·Kimberly AlexanderChristine Miaskowski

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