Association of the Glycemic Fluctuation as well as Glycemic Control with the Pancreatic β-cell Function in Japanese Subjects with Type 2 Diabetes Mellitus.

Internal Medicine
Maiko TakaiHideaki Kaneto

Abstract

Objective It is important to preserve the pancreatic β-cell function in order to maintain good glycemic control for a long period. The aim of this study was to examine which factors are associated with the β-cell function in subjects with type 2 diabetes mellitus. Methods A total of 372 subjects with type 2 diabetes who had been hospitalized for the amelioration of their glycemic control and/or education about diabetes in Kawasaki Medical School Hospital were included in this study. We evaluated the remnant β-cell function as the HOMA-%β using the computer software program HOMA2 and estimated the glycemic fluctuation with the glycoalbumin (GA)/hemoglobin A1c (HbA1c) ratio. In addition, we divided the subjects into a relatively young group (<65 years old) (n=210) and an elderly group (≥65 years old) (n=162) and performed several analyses in each group. Results The GA/HbA1c ratio, GA and HbA1c were independent determinant factors for the HOMA-%β regardless of age. We obtained almost the same results even after excluding those subjects using insulin secretagogues. These data suggest that the glycemic fluctuation and glycemic control are associated with the remnant β-cell function in Japanese subjects with type 2 diabetes. Conclusi...Continue Reading

References

Jan 22, 2005·Science·Christopher J Rhodes
Jul 11, 2006·The Journal of Clinical Investigation·Marc Prentki, Christopher J Nolan
Aug 21, 2010·Endocrine Journal·Masafumi Koga, Soji Kasayama
Oct 3, 2012·PloS One·Akifumi OgawaMasayoshi Shichiri
Aug 9, 2013·The New England Journal of Medicine·Paul K CraneEric B Larson
Mar 21, 2015·International Journal of Molecular Sciences·Hideaki Kaneto, Taka-aki Matsuoka
Sep 4, 2016·Journal of Diabetes and Its Complications·Tomoe KinoshitaHideaki Kaneto

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Software Mentioned

HOMA2 Homeostasis Model Assessment calculator
JMP

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