Association of the hOGG1 Ser326Cys polymorphism with gynecologic cancer susceptibility: a meta-analysis.

Bioscience Reports
Yongzhong ShiXia Zhang

Abstract

The association between the hOGG1 Ser326Cys polymorphism and gynecologic cancer susceptibility is inconclusive. We performed a comprehensive meta-analysis to precisely estimate of the impact of the hOGG1 Ser326Cys polymorphism on gynecologic cancer susceptibility. Electronic databases including PubMed, Embase, WanFang, and the China National Knowledge Infrastructure were searched for relevant studies. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were determined to assess the strength of the association. Fourteen studies with 2712 cases and 3638 controls were included in the final meta-analysis. The pooled analysis yielded a significant association between the hOGG1 Ser326Cys polymorphism and overall gynecologic cancer susceptibility (dominant model: OR = 1.16, 95% CI = 1.03-1.30, P=0.017). A significantly higher gynecologic cancer risk was found for the European population (homozygous model: OR = 2.17, 95% CI = 1.80-2.61, P<0.001; recessive model: OR = 2.11, 95% CI = 1.41-3.17, P<0.001; dominant model: OR = 1.29, 95% CI = 1.12-1.48, P<0.001; and allele model: OR = 1.40, 95% CI = 1.13-1.74, P=0.002), but not in the Asian population. The stratified analysis by cancer type revealed endometrial cancer was sig...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Apr 25, 2000·Archives of Biochemistry and Biophysics·S Boiteux, J P Radicella
Feb 22, 2001·Science·R D WoodT Lindahl
May 18, 2001·Nature·J H Hoeijmakers
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·David M WilsonDaniel R McNeill
Nov 6, 2003·Toxicology·Markus ChristmannBernd Kaina
Apr 15, 2010·Genetics and Molecular Research : GMR·R AttarB Agachan
Oct 15, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xiaoxiang ChenYaping Wang
Jan 25, 2012·Medical Oncology·Zeynep Birsu CincinBedia Cakmakoglu
May 1, 2012·Pathology Oncology Research : POR·Anna SobczukJanusz Blasiak
Oct 16, 2012·International Journal of Environmental Research and Public Health·Ida CasorelliMargherita Bignami
Aug 6, 2013·Genetic Testing and Molecular Biomarkers·Zhan WangYan Geng
Nov 1, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Satoyo HosonoHideo Tanaka
Jul 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Magdalena M MichalskaBeata Smolarz
Mar 8, 2017·BMC Medical Research Methodology·Jørn WetterslevChristian Gluud
Oct 24, 2018·International Journal of Cancer. Journal International Du Cancer·J FerlayF Bray

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

GTEx
Trial Sequential Analysis Viewer ( TSA )
STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Qiuyin CaiWei Zheng
© 2021 Meta ULC. All rights reserved