Association of the homeobox transcription factor gene ENGRAILED 2 with autistic disorder in Chinese children

Neuropsychobiology
Pinchen YangSuh-Hang Hank Juo

Abstract

Autism is a neurodevelopmental disorder with a strong genetic component. Previous studies have mapped the disease to chromosome 7q, where the homeobox transcription factor ENGRAILED 2 (EN2) gene is located. EN2 is specifically involved in patterning the region that gives rise to the cerebellum. In the present work, we carried out a case-control study to determine whether 2 intronic single-nucleotide polymorphisms (SNPs) of EN2 are a susceptibility to autism in a Han Chinese population. We enrolled 184 cases of DSM-IV-TR diagnosed autistic disorder, 225 controls of unrelated healthy volunteers and 409 randomly selected controls from the community who lives in the adjacent geographical regions for this study. Two SNPs (rs1861972, rs1861973) at the EN2 gene that have been reported to be associated with autism underwent analysis among our studied cohorts. Both the UNPHASE and PHASE statistical programs were utilized for evaluating the association of EN2 SNPs with autism based on allelic and genotypic frequencies and haplotype compositions accompanied with the goodness-of-fit method of the chi(2) test. The gender difference was also investigated by using 2-side Fisher's exact test treated as a covariate in logistic regression analys...Continue Reading

References

Jun 8, 2001·Human Molecular Genetics·UNKNOWN International Molecular Genetic Study of Autism Consortium (IMGSAC)
Aug 28, 2001·Nucleic Acids Research·S YeI N Day
Dec 6, 2001·Nature Reviews. Genetics·S E Folstein, B Rosen-Sheidley
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Eric Fombonne
May 4, 2004·Pediatrics·Rebecca MuhleIsabelle Rapin
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Margaret L Bauman, Thomas L Kemper
Aug 2, 2006·Molecular Psychiatry·G D SchellenbergE M Wijsman
Oct 24, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lifang WangDai Zhang

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Citations

Nov 27, 2009·European Child & Adolescent Psychiatry·Christine M FreitagRegina Waltes
Jul 26, 2012·PloS One·Jennifer BrielmaierJacqueline N Crawley
May 18, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yi-Ling ChienWei-Hsien Chien
Jan 23, 2010·Physiology & Behavior·Danielle C LlanezaCheryl A Frye
Jul 21, 2009·Biological Psychiatry·Rym BenayedJames H Millonig
May 24, 2017·Medical Molecular Morphology·Hidenori ItoKoh-Ichi Nagata
Aug 28, 2018·Frontiers in Neuroanatomy·Francisco Carratala-MarcoSalvador Martinez
Jun 17, 2019·Journal of Neurodevelopmental Disorders·Santosh KumarChengji J Zhou
Jul 17, 2021·Behavioural Brain Research·Mimi L PhanBenjamin A Samuels
Jul 10, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Júlio Santos-TerraCarmem Gottfried

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