Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis.

Arthritis and Rheumatism
Anne HinksBritish Society of Paediatric and Adolescent Rheumatology Study Group

Abstract

IL2RA/CD25, the gene for interleukin-2 receptor alpha, is emerging as a general susceptibility gene for autoimmune diseases because of its role in the development and function of regulatory T cells and the association of single-nucleotide polymorphisms (SNPs) within this gene with type 1 diabetes mellitus (DM), Graves' disease, rheumatoid arthritis (RA), and multiple sclerosis (MS). The aim of this study was to determine whether SNPs within the IL2RA/CD25 gene are associated with juvenile idiopathic arthritis (JIA). Three SNPs within the IL2RA/CD25 gene, that previously showed evidence of an association with either RA, MS, or type 1 DM, were selected for genotyping in UK JIA cases (n=654) and controls (n=3,849). Data for 1 SNP (rs2104286) were also available from North American JIA cases (n=747) and controls (n=1,161). Association analyses were performed using Plink software. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. SNP rs2104286 within the IL2RA/CD25 gene was significantly associated with UK JIA cases (OR for the allele 0.76 [95% CI 0.66-0.88], P for trend=0.0002). A second SNP (rs41295061) also showed modest evidence for association with JIA (OR 0.80 [95% CI 0.63-1.0], P=0.05). Association wit...Continue Reading

Associated Clinical Trials

References

Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·N SharfeC M Roifman
Nov 19, 1997·Arthritis and Rheumatism·M B MoroldoE H Giannini
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·K G BeckerJ M Trent
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Baecher-AllanD A Hafler
Oct 5, 2002·Rheumatology·W ThomsonUNKNOWN British Paediatric Rheumatology Study Group
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ismé M de KleerBerent Prakken
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jun 9, 2005·The Journal of Experimental Medicine·Claudia R RuprechtFederica Sallusto
Mar 6, 2007·Lancet·Angelo Ravelli, Alberto Martini
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Jul 31, 2007·The New England Journal of Medicine·UNKNOWN International Multiple Sclerosis Genetics ConsortiumStephen L Hauser
Sep 7, 2007·The New England Journal of Medicine·Robert M PlengePeter K Gregersen
Oct 16, 2007·Rheumatic Diseases Clinics of North America·Jennifer E Weiss, Norman T Ilowite
Nov 6, 2007·Nature Genetics·Wendy ThomsonJane Worthington

❮ Previous
Next ❯

Citations

Jul 29, 2010·Zeitschrift für Rheumatologie·J P Haas
Mar 2, 2011·Zeitschrift für Rheumatologie·U Wagner
Dec 4, 2013·Expert Reviews in Molecular Medicine·Anne M Pesenacker, Lucy R Wedderburn
Oct 7, 2009·Nature Reviews. Rheumatology·Claudia MacaubasElizabeth D Mellins
Apr 23, 2010·The New England Journal of Medicine·Ying JinRichard A Spritz
Dec 8, 2009·Rheumatology·Justine A EllisAnne-Louise Ponsonby
Aug 14, 2009·Annals of the Rheumatic Diseases·Anne HinksWendy Thomson
Nov 17, 2012·Pediatric Rheumatology Online Journal·Justine A EllisJane E Munro
May 14, 2010·Genes and Immunity·A HinksW Thomson
Apr 29, 2010·Current Rheumatology Reports·Sheila Angeles-Han, Sampath Prahalad
Feb 22, 2014·Autoimmunity·Dimitry A ChistiakovAlexander A Baranov
Mar 29, 2011·Neurologic Clinics·Joseph P McElroy, Jorge R Oksenberg
May 11, 2010·Molecular and Cellular Probes·Sabine Hoffjan, Denis A Akkad
Oct 27, 2009·Best Practice & Research. Clinical Rheumatology·Patricia Woo, Robert A Colbert
Aug 26, 2015·Journal of Autoimmunity·Aimee O Hersh, Sampath Prahalad
Nov 23, 2012·Clinical Endocrinology·Zhi-Yi SongHuai-Dong Song
Feb 19, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kevin GoudyRosa Bacchetta
Aug 19, 2014·Survey of Ophthalmology·Viera Kalinina AyusoJoke H de Boer
Jun 1, 2016·Frontiers in Immunology·Jacobo López-AbenteMarjorie Pion
Feb 2, 2017·Scandinavian Journal of Rheumatology·M Alberdi-SaugstrupUNKNOWN Nordic Study Group of Pediatric Rheumatology (NoSPeR)
Jul 3, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Yves-Marie PersIsabelle Touitou
Sep 29, 2018·Acta Paediatrica·Anders ÖmanLillemor Berntson
Dec 17, 2011·The Journal of Rheumatology·Heini PohjankoskiAnneli Savolainen
Apr 16, 2019·Chemistry, an Asian Journal·Dandan XuXing Ma
Aug 30, 2017·Clinical Reviews in Allergy & Immunology·Marco CattaliniRolando Cimaz
Oct 11, 2019·Nature Reviews. Rheumatology·Nathalie C Lambert
Nov 23, 2017·Frontiers in Immunology·Nicholas A J DawsonMegan K Levings

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

Haploview
Stata
Plink

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.