Association of the IL4R single-nucleotide polymorphism I50V with rapidly erosive rheumatoid arthritis

Arthritis and Rheumatism
Iryna ProtsHendrik Schulze-Koops

Abstract

To examine whether single-nucleotide polymorphisms (SNPs) of the interleukin-4 receptor gene IL4R influence susceptibility to, or radiographic progression in, rheumatoid arthritis (RA). The contribution of 2 SNPs (I50V and Q551R) in the coding region of IL4R to RA susceptibility was analyzed by allele-specific polymerase chain reaction in a case-control study of 471 RA patients and 371 healthy controls. Patients with available radiographs of the hands and feet obtained 2 years after disease onset (n = 302) were stratified retrospectively according to radiologic outcome into an erosive and a nonerosive group to evaluate the association between IL4R SNPs and disease progression. No differences in the genotype and allele frequencies of the I50V or Q551R SNPs were identified between the RA patients and healthy controls. In contrast, significant differences in the distribution of I50V IL4R SNP genotypes between patients with erosive and nonerosive disease were observed (chi2 = 15.68, P = 0.0004). Bone erosions at 2 years after disease onset were present in 68.1% of patients homozygous for the V50 allele compared with 37.0% of patients homozygous for the I50 allele (odds ratio 3.86, P < 0.0001). This association was independent of in...Continue Reading

References

Jan 1, 1991·Annals of the Rheumatic Diseases·C M Deighton, D J Walker
Sep 1, 1989·Clinical Genetics·C M DeightonD F Roberts
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·A K SimonJ Sieper
Oct 1, 1993·British Journal of Rheumatology·A J SilmanW E Ollier
Feb 24, 1997·Biochemical and Biophysical Research Communications·K DeichmannJ Kuehr
Dec 11, 1997·The New England Journal of Medicine·G K HersheyT A Chatila
Jul 8, 1998·Lancet·W L van der GraaffR A van Lier
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·F CornélisUNKNOWN ECRAF
Jan 14, 1999·International Immunology·S ShiozawaS Imura
Jun 8, 1999·Annual Review of Immunology·K NelmsW E Paul
Jun 12, 1999·Arthritis and Rheumatism·M F SeldinP K Gregersen
Nov 30, 2000·The New England Journal of Medicine·J M BathonB K Finck
Nov 30, 2000·The New England Journal of Medicine·P E LipskyUNKNOWN Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
Sep 25, 2001·Lancet·D M Lee, M E Weinblatt
Dec 13, 2001·American Journal of Human Genetics·Timothy D HowardEugene R Bleecker
Feb 13, 2002·Arthritis and Rheumatism·James R O'Dell
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kimberly A RismaGurjit K Khurana Hershey
Oct 29, 2002·Diabetes·Daniel B MirelJanelle A Noble
May 16, 2003·Nature·Gary S Firestein
May 16, 2003·American Journal of Human Genetics·Teodorica L BugawanHenry A Erlich
Feb 6, 2004·The Journal of Experimental Medicine·Alla SkapenkoHendrik Schulze-Koops
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Linda StephensonMark Boothby
Apr 19, 2005·Arthritis Research & Therapy·Alla SkapenkoHendrik Schulze-Koops

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Citations

Jan 16, 2009·Zeitschrift für Rheumatologie·S Drynda, J Kekow
Sep 24, 2010·Zeitschrift für Rheumatologie·M Pierer, U Wagner
May 21, 2013·Immunology Letters·Ahmet InanirGorkem Kismali
Jul 29, 2009·Nature Reviews. Rheumatology·Alla SkapenkoHendrik Schulze-Koops
Apr 7, 2007·Current Opinion in Rheumatology·Kate L Mitchell, David S Pisetsky
Mar 30, 2007·Annual Review of Biomedical Engineering·Sobin Kim, Ashish Misra
Feb 20, 2007·Arthritis Research & Therapy·Steven K LundyDavid A Fox
Sep 14, 2007·Arthritis Research & Therapy·Viviana LutzkyRanjeny Thomas
Apr 9, 2008·Arthritis Research & Therapy·Annette H M van der Helm-van Mil, Tom W J Huizinga
Nov 26, 2008·Arthritis Research & Therapy·Andrew P Cope
Jul 16, 2008·Arthritis Research & Therapy·Ioanna MarinouAnthony G Wilson
May 6, 2008·Best Practice & Research. Clinical Rheumatology·Claire L Gorman, Andrew P Cope
Jan 23, 2015·Zeitschrift für Rheumatologie·J Leipe, H-D Chang
Aug 4, 2016·Clinical Reviews in Allergy & Immunology·Larissa Lumi Watanabe IshikawaAlexandrina Sartori
Apr 19, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·Yousri HusseinAmany Abul-Saoud
Jul 19, 2015·Cytokine·Sarah M McCormick, Nicola M Heller
Sep 2, 2009·Anais Da Academia Brasileira De Ciências·Luis E C Andrade
Mar 8, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lars-Oliver TykocinskiHanns-Martin Lorenz
Jun 30, 2016·Organic & Biomolecular Chemistry·Ulla Jakobsen, Stefan Vogel
Aug 11, 2007·International Journal of Cancer. Journal International Du Cancer·Emma L IvanssonUlf B Gyllensten
Jul 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew Q FordAchsah D Keegan
Nov 30, 2010·Biochimica Et Biophysica Acta·Elena V BichenkovaKenneth T Douglas

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