Association of the Mediterranean Diet With Onset of Diabetes in the Women's Health Study.

JAMA Network Open
Shafqat AhmadSamia Mora

Abstract

Higher Mediterranean diet (MED) intake has been associated with reduced risk of type 2 diabetes, but underlying biological mechanisms are unclear. To characterize the relative contribution of conventional and novel biomarkers in MED-associated type 2 diabetes risk reduction in a US population. This cohort study was conducted among 25 317 apparently healthy women. The participants with missing information regarding all traditional and novel metabolic biomarkers or those with baseline diabetes were excluded. Participants were invited for baseline assessment between September 1992 and May 1995. Data were collected from November 1992 to December 2017 and analyzed from December 2018 to December 2019. MED intake score (range, 0 to 9) was computed from self-reported dietary intake, representing adherence to Mediterranean diet intake. Incident cases of type 2 diabetes, identified through annual questionnaires; reported cases were confirmed by either telephone interview or supplemental questionnaire. Proportion of reduced risk of type 2 diabetes explained by clinical risk factors and a panel of 40 biomarkers that represent different physiological pathways was estimated. The mean (SD) age of the 25 317 female participants was 52.9 (9.9) ...Continue Reading

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Citations

Oct 10, 2021·Endocrine·Nikoletta MiliTheodora Psaltopoulou
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Oct 25, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Anne M FitzpatrickJocelyn R Grunwell

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
nuclear magnetic resonance
NMR
acetylation

Software Mentioned

Stata
SAS

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