Association of the miR-196a2, miR-146a, and miR-499 Polymorphisms with Asthma Phenotypes in a Korean Population

Molecular Diagnosis & Therapy
Hoang Kim Tu TrinhSeung-Hyun Kim

Abstract

MicroRNAs (miRNAs) modulate expressions of inflammatory genes, thereby regulating inflammatory responses. Single nucleotide polymorphisms (SNPs) in miRNAs could affect their efficiency in binding to messenger RNAs (mRNAs). We investigated the associations of miRNA SNPs with asthma phenotypes. miR-196a2 (rs11614913 T>C), miR-146a (rs2910164 C>G), and miR-499 (rs3746444 A>G) were genotyped in 347 asthma patients and 172 normal healthy controls (NCs). The CT/CC genotype of miR-196a2 rs11614913 was associated with eosinophilic asthma (p = 0.004) and a higher sputum eosinophil count compared with the TT genotype (p = 0.003). The CG/GG genotype of miR-146a rs2910164 tended to be associated with higher bronchial hyperresponsiveness to methacholine (PC20) compared with the CC genotype. The AG/GG genotype of miR-499 rs3746444 was associated with higher predicted values of forced expiratory volume in 1 s (%FEV1) compared with the AA genotype (p = 0.008). Genetic polymorphisms in miR-196a2, miR-146a, and miR-499 could be potential biomarkers for asthma phenotypes and targets for asthma treatments in a Korean population.

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Citations

Dec 1, 2017·Genes·Beata NarożnaAleksandra Szczepankiewicz
May 30, 2019·Archivum Immunologiae Et Therapiae Experimentalis·Krzysztof Specjalski, Ewa Jassem
Apr 21, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jing DongFangting Lu
Jun 12, 2020·Asia-Pacific Journal of Clinical Oncology·Guofeng YangMingqiang Kang
Feb 27, 2020·Current Opinion in Pulmonary Medicine·Krzysztof Specjalski, Marek Niedoszytko
Dec 3, 2020·International Journal of Molecular Sciences·Émile BélangerCatherine Laprise

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Methods Mentioned

BETA
biopsy
Assay

Software Mentioned

SPSS

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