Association of the MTHFR rs1801131 and rs1801133 variants in sporadic Parkinson's disease patients

Neuroscience Letters
Lamei YuanHao Deng

Abstract

Parkinson's disease (PD) is a common age-dependent neurodegenerative movement disorder related to multiple factors, and genetic factors play an important role in the pathogenesis of PD. Variants in the methylenetetrahydrofolate reductase gene (MTHFR), a gene encoding a folate-dependent enzyme that is involved in homocysteine metabolism, have been reported to be associated with PD. To explore the role of the MTHFR gene in the development of PD in Chinese Han population, we analyzed two MTHFR variants (rs1801131 and rs1801133) in a patient cohort consisting of 512 patients with PD from mainland China and a control cohort consisting of 512 age, gender and ethnicity matched normal subjects. Statistically significant differences in genotypic and allelic frequencies were detected in the MTHFR variant rs1801133 (P=0.022 and 0.007, respectively; odds ratio=0.780, 95% confidence interval=0.651-0.934). In addition, the A-T haplotype of rs1801131-rs1801133 showed a protective role against PD development (P=0.007, odds ratio=0.779, 95% confidence interval=0.650-0.933). Our results suggested that the T allele of rs1801133 variant and A-T haplotype of rs1801131-rs1801133 in the MTHFR gene may decrease the risk of developing PD in Chinese Han...Continue Reading

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Citations

Mar 4, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Bei ZhangGang Li
Aug 5, 2017·Frontiers in Molecular Neuroscience·Ernesto Miranda-MoralesOscar Arias-Carrión
Feb 25, 2021·Sleep & Breathing = Schlaf & Atmung·Yumeng HuangJianfang Ma
Jul 6, 2021·Saudi Journal of Biological Sciences·Mikhlid H AlmutairiAbdelhabib Semlali

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