Association of the prion protein gene with individual tissue weights in Scottish Blackface sheep

Journal of Animal Science
R M SawalhaB Villanueva

Abstract

This study investigated associations of prion protein (PrP) genotype with body composition and weight traits of Scottish Blackface ewes. Body composition was predicted using computer tomography (CT) scans to estimate muscle, carcass fat, internal fat, and bone weights. The traits were measured at 4 key seasonal production points (pre-mating, pregnancy, midlactation, and weaning) over 4 production cycles (2 to 5 yr old). There were 2,413 records for each of the CT traits measured on 335 ewes, and 26,649 records for each of the body condition score and BW traits for 2,356 ewes. From 1999 to 2004, animals were genotyped to determine polymorphisms at codons 136, 154, and 171, which are associated with scrapie susceptibility. Four alleles were found in the population (ARR, AHQ, ARQ, and VRQ). The data were analyzed using a linear mixed random regression model assuming that the direct additive genetic effect was a 2nd order Legendre polynomial function of time. The PrP genotype was included in the model as a fixed effect along with other fixed factors with significant effects (P < 0.05). Five separate analyses were carried out for each trait, depending on the method of classifying the PrP genotype. In the first analysis, animals were...Continue Reading

References

Jun 1, 1997·Journal of Dairy Science·J JamrozikJ C Dekkers
Nov 17, 2004·Journal of Dairy Science·M P CoffeyS Brotherstone
Nov 29, 2005·Research in Veterinary Science·R PonzM V Arruga
Apr 12, 2006·Journal of Dairy Science·L AlvarezJ J Arranz
May 16, 2006·Journal of Animal Science·Z G VitezicaJ M Elsen
May 30, 2006·The Veterinary Record·N NichollsM Baylis
Nov 29, 2007·PloS One·Rami M SawalhaBeatriz Villanueva

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