Association of the receptor for advanced glycation end products gene polymorphisms with diabetic retinopathy in type 2 diabetes: a meta-analysis

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Dongqing YuanQinghuai Liu

Abstract

To investigate the association between diabetic retinopathy (DR) in type 2 diabetes mellitus and three polymorphisms of the receptor for advanced glycation end products (RAGE) gene, -429T/C, -374T/A and Gly82Ser. A literature search was conducted through PubMed and Web of Science (up to August 31, 2011). Pooled odds ratios (ORs) were estimated using fixed-effects (FE) and random-effects (RE) models in co-dominant, recessive and dominant models. A sensitivity analysis was performed by excluding invalid studies. Six articles investigated the -429T/C polymorphism, 7 publications were associated with the -374T/A polymorphism and 5 studies were associated with Gly82Ser in DR. For the -429T/C variant, we found no significant difference between DR patients and those with diabetes without retinopathy. A significant association of allele A with DR was found in the recessive model for the -374T/A variant (RE OR = 0.64, 95% CI = 0.42-0.99, p = 0.05, p heterogeneity = 0.55). In the recessive and co-dominant models for the Gly82Ser polymorphism, the pooled ORs were positive in the fixed-effects model (FE OR = 2.89, 95% CI = 1.49-5.60, p = 0.002, p heterogeneity = 0.20; and FE OR = 3.45, 95% CI = 1.76-6.67, p = 0.0003, p heterogeneity = 0.07...Continue Reading

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Citations

Sep 14, 2012·The Review of Diabetic Studies : RDS·Mariana MureaBarry I Freedman
Jan 15, 2014·Diabetes Research and Clinical Practice·Ashok Kumar TripathiOm Prakash Kalra
Feb 23, 2017·European Journal of Clinical Investigation·Maria GiannakouMaria Alevizaki
Apr 24, 2018·Acta Ophthalmologica·Suzanne BroadgateVictor Chong
Nov 13, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Işıl İnan-ErdoğanNuray Kanbur
Mar 14, 2019·Disease Markers·Marine Serveaux-DancerVincent Sapin

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