Association of the resistin gene promoter region polymorphism with Kawasaki disease in Chinese children.

Mediators of Inflammation
Ruixi LiuQijian Yi

Abstract

The -420 C > G polymorphism located in the resistin gene (RETN) promoter has recently been suggested to play a potential role in proinflammatory conditions and cardiovascular disease. This study investigated the association of the RETN promoter polymorphism with Kawasaki disease (KD) and its clinical parameters in Chinese children. We compared patients with complete KD to incomplete KD children. Genotyping of the RETN promoter polymorphism was performed using MassARRAY system, and serum resistin levels were estimated using the sandwich enzyme immunoassay method. There was no significant difference in RETN (-420 C > G) genotypes between KD and control groups. However, the frequency of the G allele was higher in iKD patients than in cKD children due to a significantly increased frequency of the GG genotypes. Serum levels of resistin were significantly higher in KD patients than in controls regardless of the presence of coronary artery lesions (CALs). The present findings suggest that while resistin may play a role in the pathogenesis of KD, there is no apparent association between CAL and the RETN (-420 C > G) gene polymorphism in KD children. However, the diagnosis of iKD is challenging but can be supported by the presence of th...Continue Reading

References

Aug 1, 1991·The Journal of Pediatrics·K A TaubertS T Shulman
Feb 24, 2001·Nature·C M SteppanM A Lazar
Sep 18, 2001·Journal of Human Genetics·H Cao, R A Hegele
Apr 30, 2002·Diabetes·James C EngertThomas J Hudson
Nov 21, 2002·The Pediatric Infectious Disease Journal·Jane C Burns
Dec 31, 2002·Biochemical and Biophysical Research Communications·Lisa PatelStephen A Smith
Aug 25, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K AzumaT Saruta
Dec 3, 2004·Pediatrics·Jane W NewburgerUNKNOWN Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American H
Feb 16, 2005·Circulation·Muredach P ReillyDaniel J Rader
Apr 22, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·A KunnariY A Kesäniemi
Aug 10, 2005·Biochemical and Biophysical Research Communications·Haruhiko OsawaHideichi Makino
May 4, 2006·The Journal of Clinical Endocrinology and Metabolism·Claudia MenzaghiVincenzo Trischitta
Aug 17, 2006·Theoretical Biology & Medical Modelling·Nicholas Sperelakis, Lakshminarayanan Ramasamy
Dec 21, 2006·Journal of Neuroengineering and Rehabilitation·Michelle J Johnson
Mar 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Paul D AndersonMuredach P Reilly
Jun 26, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Tomoyoshi SonobeHiroshi Yanagawa
Oct 27, 2007·Social Science & Medicine·Michele Kerry Travers, Jocalyn Lawler
Jan 3, 2008·Clinical Endocrinology·Michael M HoffmannWinfried März
Feb 8, 2008·Journal of Zhejiang University. Science. B·Xiao-zhi QiaoLi-ai Yang
Mar 3, 2009·American Heart Journal·Chi-Di LiangSheung-Fat Ko
Sep 17, 2009·Journal of Cellular and Molecular Medicine·Andrej TarkowskiMaria I Bokarewa
Feb 23, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Sabir HussainQamar Javed
Apr 28, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hiroki NozueTomohiro Kamoda
Jun 3, 2011·Modern Rheumatology·Yasushi KemmotsuShinichi Kawai

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Citations

Mar 28, 2013·Computational and Mathematical Methods in Medicine·Yu-wen LvHai-tao Lv
Sep 17, 2013·Journal of the American Academy of Dermatology·Stephanie BayersAmy S Paller
Mar 10, 2015·Clinical Biochemistry·Pavithra ParthasarathyTapas K Mondal
Feb 2, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Li ZhangXiaofeng Xu
Mar 31, 2018·The Pediatric Infectious Disease Journal·Li LuoQijian Yi

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Methods Mentioned

BETA
ELISA
genotyping
ESR

Software Mentioned

MassARRAY Typer
MassARRAY RT
SPSS

Related Concepts

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