Association of the very early rise of human chorionic gonadotropin with adverse outcomes in singleton pregnancies after in vitro fertilization

Fertility and Sterility
Christopher B MorseChristos Coutifaris

Abstract

To determine if very early serum hCG, a marker of trophoblast differentiation, is associated with adverse perinatal outcomes in singleton pregnancies. Retrospective cohort study. University fertility program. A total of 360 singleton IVF live births. Serial hCG measurements were used to determine the within-woman slope for hCG (hCG rise). Primary outcomes included birth weight and gestational age at delivery. Statistical comparisons used t test, chi-square test, and linear and logistic regressions as appropriate. hCG rise was positively associated with birth weight but not gestational age at delivery. Infant sex, gestational age, and type of embryo transfer (fresh vs. frozen/thawed) were significantly associated with birth weight and confounded the associations of interest. hCG rise was slower among subjects delivering an infant with low birth weight (slope 0.386 ± 0.05 vs. 0.407 ± 0.06) or small for gestational age (slope 0.371 ± 0.07 vs. 0.406 ± 0.06). Analysis of hCG rise by quartile showed that, compared with the first quartile (slowest), subjects with a rate of hCG rise in the fourth quartile (fastest) had a significantly decreased risk of delivering an infant of low birth weight. No relationship was noted between hCG rise...Continue Reading

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Citations

Apr 5, 2017·Acta Obstetricia Et Gynecologica Scandinavica·Kristine LøsslAnja Pinborg
Dec 21, 2017·Journal of Assisted Reproduction and Genetics·Paula C BradyJanis H Fox
Oct 10, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Leonti GrinShevach Friedler
Nov 24, 2019·Archives of Gynecology and Obstetrics·Zengyan WangYanwen Xu
Oct 13, 2019·Journal of Assisted Reproduction and Genetics·Naama Al MamariMichael H Dahan

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