Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children

Disease Markers
Yapeng LuZuocheng Yang

Abstract

Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children and can result in coronary artery lesions (CALs). Thrombomodulin (TM) is a critical cofactor in the protein C anticoagulant system. The TM C1418T (rs1042579) polymorphism is associated with a high risk of cardiac-cerebral vascular diseases. But the association of the TM C1418T polymorphism with susceptibility to KD, CAL formation, and intravenous immunoglobulin (IVIG) resistance is still unclear. In our study, we examined the TM C1418T polymorphism in 122 children with KD and 126 healthy children and revealed the correlation between the TM C1418T polymorphism and KD, CAL formation, and IVIG resistance.

References

Mar 18, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Mamoru AyusawaUNKNOWN Kawasaki Disease Research Committee
Dec 16, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·UNKNOWN Japanese Circulation Society Joint Research Group
Mar 6, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Sakda Arj-OngJohn Attia
Mar 27, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Ken-Pen WengLuo-Ping Ger
Nov 3, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Ritei UeharaHiroshi Yanagawa
Oct 14, 2011·Circulation·Robert L LobatoUNKNOWN Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team
Nov 1, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Georgia AnastasiouAnthi Travlou
Jun 27, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Rupinder DograK K Talwar
Jul 4, 2012·Journal of Immunological Methods·Ronald CarnemollaVladimir R Muzykantov
Apr 9, 2013·Journal of Paediatrics and Child Health·Deane YimDavid Burgner
Oct 25, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Tomoyo YahataKazuyuki Ikeda
Jun 27, 2015·Archives of Disease in Childhood·Surjit SinghDavid Burgner
Aug 1, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Aliaa Al AzmeAhmed Jaradat
Dec 4, 2015·Yonsei Medical Journal·Kyu Yeun Kim, Dong Soo Kim

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Methods Mentioned

BETA
electrophoresis
PCR
coronary artery bypass

Software Mentioned

SPSS

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