Association of thymidylate synthase polymorphisms with gastric cancer susceptibility

International Journal of Cancer. Journal International Du Cancer
F GrazianoM Magnani

Abstract

We investigated in a case-control study a possible role of thymidylate synthase gene (TS) polymorphisms for gastric cancer susceptibility. Lymphocyte genomic DNA from 134 Italian gastric cancer patients and 139 controls was used for genotyping two polymorphisms in the TS 5'-untranslated region (5'-UTR); a double (2R) or triple (3R) 28-bp repeat and a G/C polymorphism within the triple repeats allele (3G allele). Samples were also genotyped at a 6-bp deletion/insertion (del6 or ins6) polymorphism at position 1494 in the TS 3'-untranslated region (3'-UTR). Unconditional regression with odd ratios (OR) and 95% confidence intervals (CI), haplotype and linkage disequilibrium analyses were used to investigate the association of the polymorphisms with the disease. The global allelic distribution was in Hardy-Weinberg equilibrium. Genotypes with the 3G allele (2R/3G, 3C/3G, 3G/3G) were significantly more frequent in patients than controls and were associated with gastric cancer risk (OR = 2.06; 95% CI = 1.26-3.35). A significant risk was also observed for carriers of the del6 allele in the 3'-UTR. Odds ratios for combined 3G-del6/ins6 and 3G-del6/del6 genotypes were 2.59 (95% CI = 1.36-4.94) and 2.81 (95% CI = 1.22-6.64), respectively....Continue Reading

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Citations

Feb 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wang-Hong XuXiao-Ou Shu
Feb 5, 2008·Pharmacogenomics·E OliveiraH L McLeod
Mar 29, 2014·Experimental and Molecular Pathology·Jin-hui LiuPeng-gao Dai
Nov 8, 2008·Digestive Diseases and Sciences·Wen ZhuangMao-Ling Wei
Jun 29, 2010·Molecular Genetics and Metabolism·Vikki HoWill D King
May 26, 2006·British Journal of Clinical Pharmacology·M AcuñaD Massardo
Aug 21, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Zhen YangXie-Fu Zhang
Jan 16, 2007·Drug Metabolism and Pharmacokinetics·Su-Ryang KimJun-ichi Sawada
Feb 24, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nadège NiefJacques Robert
Jan 13, 2015·Cellular Oncology (Dordrecht)·Chiara PesentiMonica Miozzo
Jan 29, 2011·Molecular Genetics and Metabolism·Vikki HoWill D King
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francesco Graziano, Kazuyuki Kawakami
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Apr 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Annamaria RuzzoMauro Magnani
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May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kazuyuki KawakamiMauro Magnani

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