Association of Thyrotropin Concentration with Chronic Kidney Disease in a Japanese General Population Cohort

Nephron
Akiko TodaYasuji Arase

Abstract

Previous studies have indicated an association between hypothyroidism and kidney dysfunction; however, few studies have investigated whether thyroid dysfunction is a risk factor for chronic kidney disease (CKD) development. And their result is not consistent. We evaluated the association of thyroid dysfunction with CKD prevalence and development by a multivariate logistic regression analysis. In cross-sectional and longitudinal studies, 16,390 subjects and 7,609 subjects, respectively, who underwent annual health check-ups were analyzed. We categorized the subjects into the following 4 groups based on their serum thyrotropin (TSH) -concentrations: below-normal (TSH < 0.54 mU/L), lower-normal -(0.54-2.40 mU/L), higher-normal (2.41-4.26 mU/L) and above-normal (> 4.26 mU/L). Subjects with eGFR <60 mL/min/1.73 m2 were determined to have CKD. The cross-sectional study revealed a positive correlation between TSH concentration and CKD -prevalence. Compared with the lower-normal TSH group, the ORs and 95% CIs of CKD prevalence were 0.61 (0.45-0.82, p = 0.001) for the below-normal group, 1.49 (1.33-1.67, p < 0.001) for the higher-normal group, and 1.90 (1.57-2.30, p < 0.001) for the above-normal group. The longitudinal study revealed th...Continue Reading

Citations

Sep 5, 2019·Current Opinion in Nephrology and Hypertension·Connie M Rhee
Nov 20, 2019·Journal of Family Medicine and Primary Care·Faisal AlshammariMohammad Alfifi
Feb 9, 2020·Scientific Reports·Benjamin SchairerWolfgang Winnicki
Jun 19, 2021·Seminars in Nephrology·Yoko NarasakiConnie M Rhee

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