Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility

Immunologic Research
Mamoona Noreen, Muhammad Arshad

Abstract

Toll like receptors (TLRs) play a crucial role in regulation of innate as well as adaptive immunity. TLRs recognize a distinct but limited repertoire of conserved microbial products. Ligand binding to TLRs activates the signaling cascade and results in activation of multiple inflammatory genes. Variation in this immune response is under genetic control. Polymorphisms in genes associated with inflammatory pathway especially influence the outcome of diseases. TLR2 makes heterodimer with TLR1 or TLR6 and recognizes a wide variety of microbial ligands. In this review, we summarize studies of polymorphisms in genes encoding TLR1, TLR2, TLR4, TLR6, and most polymorphic adaptor protein, Mal/TIRAP, revealing their effect on susceptibility to diseases.

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Citations

Jul 25, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tom Eirik SmelandHege Vangstein Aamot
Jun 9, 2018·Asian-Australasian Journal of Animal Sciences·Dae-Jin KwonKi-Duk Song
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May 4, 2021·BioMed Research International·Ghulam MustafaRawaba Arif
Jun 20, 2021·Immunologic Research·Asma KomalAttalla F El-Kott
Jun 15, 2021·Saudi Journal of Biological Sciences·Mamoona NoreenMuhammad Arshad

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