Association of TLR4 and TLR9 gene polymorphisms and haplotypes with cervicitis susceptibility

PloS One
Alex ChauhanNeeraj Jain

Abstract

Cervicitis is one of the major health problems amongst women caused by infection of various pathogens including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV) as well as human papillomavirus (HPV), and persistent cervical inflammation is one of the etiologic agents of cervical cancer. Toll-like receptors (TLRs) play an important role in the recognition and subsequent elimination of these pathogens. Variations in the Toll-like receptor genes influence susceptibility to pathogens as well as disease progression independently. Ten single nucleotide polymorphisms, five each of TLR4 and TLR9 genes were analyzed among 130 cervicitis patients and 150 controls either using polymerase chain reaction-restriction fragment length polymorphism or allele specific-PCR. T. vaginalis infection was found at the highest frequency (30.7%) as compared to C. trachomatis (1.5%), N. gonorrhoeae (2.3%) and HPV (4.6%) infections in cervicitis patients. TLR4 rs11536889 CC (age-adjusted OR, 2.469 [95% CI, 1.499 to 4.065]; p < 0.001) and TLR9 rs187084 TC (age-adjusted OR, 2.165 [95% CI, 1.267-3.699]; p = 0.005) genotypes showed the higher distribution in cervicitis patients compared to controls. In addition, TLR4 rs115368...Continue Reading

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Citations

Aug 8, 2020·Scandinavian Journal of Immunology·Sonal YadavManisha Yadav
Feb 23, 2020·Life Sciences·Luiz Antonio LupiLuiz Gustavo de Almeida Chuffa
Aug 28, 2021·World Journal of Clinical Cases·Lorena Elena MelițCarmen Duicu

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Methods Mentioned

BETA
biopsies
PCR

Software Mentioned

FAMHAP
Haploview
Power
Locusview

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