Abstract
Molecular mimicry between Campylobacter jejuni lipopolysaccharide and host gangliosides induces an immune response leading to axonal damage and Guillain-Barré syndrome (GBS). TLR polymorphisms are associated with many autoimmune diseases. The role of the TLR4 gene in GBS susceptibility largely remains unknown. We investigated TLR4 polymorphism in GBS. One hundred and twenty GBS patients and 150 healthy controls were included. TLR4 (Asp299Gly and Thr399Ile) genes were studied by PCR-RFLP. TLR4 (Asp299Gly) polymorphism was significantly associated with GBS (p, 0.045; OR, 8.75; 95% CI, 1.05-72.88); only acute motor axonal neuropathy (AMAN) was associated with Gly299Gly homozygote (p, 0.027; OR, 12.40; 95% CI, 1.33-115.77) and Thr399Ile (p, 0.019; OR, 3.42; 95% CI, 1.22-9.54) heterozygote, and TLR4-399Ile allele (p, 0.045; OR, 2.63; 95% CI, 1.02-6.75) compared to controls. In conclusion, TLR4 (Asp299Gly) polymorphism is associated with an increased susceptibility to GBS. Besides Asp299Gly, AMAN subtype is also associated with Thr399Ile polymorphism.
References
Jan 1, 1990·Annals of Neurology·A K Asbury, D R Cornblath
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jun 1, 1995·Brain : a Journal of Neurology·J W GriffinD R Cornblath
Jun 1, 1995·Brain : a Journal of Neurology·T W HoG M McKhann
Aug 1, 1995·Brain : a Journal of Neurology·E J RedfordK J Smith
Jan 1, 1996·Annals of Neurology·J W GriffinA K Asbury
Sep 1, 1997·Molecular Biology and Evolution·N InomataT Yamazaki
Dec 13, 1997·The Journal of Infectious Diseases·B M Allos
Dec 31, 1997·Neurology·H S WuJ Zhang
May 26, 1998·Journal of Neuroimmunology·J ZhuH Link
Aug 26, 1998·Neurology·K A SheikhJ W Griffin
Nov 18, 1998·Annals of Neurology·R D HaddenA V Swan
Feb 27, 1999·Current Opinion in Immunology·E B Kopp, R Medzhitov
Apr 10, 1999·The Journal of Biological Chemistry·J C ChowF Gusovsky
Jun 3, 2000·Nature Genetics·N C ArbourD A Schwartz
Jun 20, 2001·Trends in Cell Biology·J L Imler, J A Hoffmann
Jul 31, 2001·Nature Immunology·S AkiraT Kaisho
Aug 15, 2001·Acta Odontologica Scandinavica·T Kaisho, S Akira
Sep 1, 2001·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·E LorenzJ G Clark
May 9, 2002·Archives of Internal Medicine·Eva LorenzDavid A Schwartz
Aug 24, 2002·Pediatric Research·Eva LorenzDavid A Schwartz
Oct 31, 2002·The Journal of Infectious Diseases·Doreen M AgneseStephen F Lowry
Dec 24, 2002·Current Opinion in Immunology·Shizuo Akira
Jan 14, 2003·Annual Review of Immunology·Kiyoshi TakedaShizuo Akira
Dec 4, 2003·Tissue Antigens·E SánchezJ Martín
Mar 17, 2004·Arthritis and Rheumatism·Rachael KildingAnthony G Wilson
Apr 15, 2004·Journal of Neuroimmunology·Karin GeleijnsPieter A van Doorn
Apr 22, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Sushmita SinhaSanjeev Jha
Aug 12, 2004·Neurology·S KuwabaraN Yuki
Dec 25, 2004·Infection and Immunity·Morikazu AkamineAtsushi Saito
Jun 24, 2005·Inflammatory Bowel Diseases·Stephan BrandThomas Ochsenkühn
Jul 16, 2005·Leukemia & Lymphoma·Stephan HellmigStefan Schreiber
Aug 4, 2006·Carcinogenesis·L HouW H Chow
Oct 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bart FerwerdaMihai G Netea
Dec 18, 2007·Human Immunology·B R AchyutBalraj Mittal
Feb 29, 2008·Yonsei Medical Journal·Yeun Sun KimIe Byung Park
Aug 5, 2011·The American Journal of Tropical Medicine and Hygiene·Kis DjamiatunSultana M H Faradz
Citations
Mar 29, 2012·Rheumatology International·Arpita Myles, Amita Aggarwal
Sep 4, 2013·BioMed Research International·Kishan Kumar Nyati, Roopanshi Nyati
Oct 23, 2015·International Urology and Nephrology·Kamini SinghJanmejai Kumar Srivastava
Oct 10, 2015·Mediators of Inflammation·Ying WangHong-Liang Zhang
Jan 24, 2015·Mediators of Inflammation·Kishan Kumar Nyati, Kashi Nath Prasad
Jan 30, 2018·Cellular & Molecular Immunology·Yhojan RodríguezJuan-Manuel Anaya
May 24, 2011·Molecular Biology Reports·Hong JiaoLihua Wang
Mar 21, 2012·Glia·Silvia Alfonso-LoechesConsuelo Guerri
May 6, 2015·Expert Review of Vaccines·Jennifer A WhitakerGregory A Poland
Oct 4, 2011·Neurochemical Research·Donna M ByersLouis N Irwin
Jul 22, 2014·Journal of the Peripheral Nervous System : JPNS·Stefan Blum, Pamela A McCombe
Dec 21, 2018·British Journal of Biomedical Science·S VidyantT N Dhole
Jan 1, 2015·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Bamidele Abiodun IwalokunPhilip Agomo
Apr 26, 2019·Annals of Clinical and Translational Neurology·Israt JahanZhahirul Islam
Feb 10, 2020·Journal of Molecular Neuroscience : MN·Zahra Pour Mohammad AliMohammad Mahdi Eftekharian
Oct 9, 2020·Journal of Molecular Neuroscience : MN·Amin SafaSoudeh Ghafouri-Fard
Dec 23, 2020·Medicine·Zhikang ZhaoHongbo Liu
Mar 24, 2021·Journal of Neuroinflammation·Oladayo OladiranJi Zhang
Sep 1, 2017·Endocrine Regulations·E T ZaharievaA S Savov
May 6, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Mohammad AladawiEzequiel Piccione
Jul 12, 2021·Journal of Neuroimmunology·Shaghayegh KhanmohammadiNima Rezaei
Sep 23, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Luis Querol, Cinta Lleixà
Nov 27, 2020·Current Pharmaceutical Design·Jiangan XieYongqun He