Association of TLR4 Asp299Gly and Thr399Ile polymorphisms with Guillain-Barré syndrome in Northern Indian population

Journal of Neuroimmunology
K K NyatiS Pradhan

Abstract

Molecular mimicry between Campylobacter jejuni lipopolysaccharide and host gangliosides induces an immune response leading to axonal damage and Guillain-Barré syndrome (GBS). TLR polymorphisms are associated with many autoimmune diseases. The role of the TLR4 gene in GBS susceptibility largely remains unknown. We investigated TLR4 polymorphism in GBS. One hundred and twenty GBS patients and 150 healthy controls were included. TLR4 (Asp299Gly and Thr399Ile) genes were studied by PCR-RFLP. TLR4 (Asp299Gly) polymorphism was significantly associated with GBS (p, 0.045; OR, 8.75; 95% CI, 1.05-72.88); only acute motor axonal neuropathy (AMAN) was associated with Gly299Gly homozygote (p, 0.027; OR, 12.40; 95% CI, 1.33-115.77) and Thr399Ile (p, 0.019; OR, 3.42; 95% CI, 1.22-9.54) heterozygote, and TLR4-399Ile allele (p, 0.045; OR, 2.63; 95% CI, 1.02-6.75) compared to controls. In conclusion, TLR4 (Asp299Gly) polymorphism is associated with an increased susceptibility to GBS. Besides Asp299Gly, AMAN subtype is also associated with Thr399Ile polymorphism.

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Citations

Sep 4, 2013·BioMed Research International·Kishan Kumar Nyati, Roopanshi Nyati
Oct 10, 2015·Mediators of Inflammation·Ying WangHong-Liang Zhang
Jan 24, 2015·Mediators of Inflammation·Kishan Kumar Nyati, Kashi Nath Prasad
Jan 30, 2018·Cellular & Molecular Immunology·Yhojan RodríguezJuan-Manuel Anaya
May 24, 2011·Molecular Biology Reports·Hong JiaoLihua Wang
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Dec 21, 2018·British Journal of Biomedical Science·S VidyantT N Dhole
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Apr 26, 2019·Annals of Clinical and Translational Neurology·Israt JahanZhahirul Islam
Feb 10, 2020·Journal of Molecular Neuroscience : MN·Zahra Pour Mohammad AliMohammad Mahdi Eftekharian
Oct 9, 2020·Journal of Molecular Neuroscience : MN·Amin SafaSoudeh Ghafouri-Fard
May 6, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Mohammad AladawiEzequiel Piccione
Jul 12, 2021·Journal of Neuroimmunology·Shaghayegh KhanmohammadiNima Rezaei
Sep 23, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Luis Querol, Cinta Lleixà

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