Association of TNF-α Promoter Polymorphism with HBV Associated Disease Outcome Among HBV Infected Patients from Orissa, Southern Part of East India

Journal of Clinical and Experimental Hepatology
Rajesh PanigrahiRunu Chakravarty

Abstract

TNF-α promoter polymorphism has been known to be a potential predictive factor in patients with HBV infection. We therefore tried to investigate whether the TNF-α promoter polymorphism at position -238, -857 and -863 was associated with the outcome of HBV infection in a population from Orissa, southern part of East India. A total of 195 patients recruited for the study were classified into 85 controls and 110 HBV infected cases, which included 34 IC, 30 CLD, 32 LC and 14 HCC patients. The polymorphisms at the respective sites were detected by a PCR-RFLP followed by statistical analysis. The frequency of the genotype -238 GG and the allele -238G in the cases (89.0% and 92.7% respectively) was significantly higher than that in the controls (68.2% and 82.2% respectively) (P < 0.001, OR = 3.8 and P = 0.001, OR = 2.73). Whereas the -238 GA genotype was significantly high in the control group (28.2%) when compared to the cases (7.2%) (P < 0.001, OR = 0.2). Similarly, the frequency of -863CC and the allele -863C was significantly higher among the cases (24.5% and 49.5%) compared to controls (1.17% and 34.7%), (P < 0.001, OR = 27.32 and P = 0.003, OR = 1.85), whereas the -863CA genotype was significantly high in the controls (67.0%) wh...Continue Reading

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Citations

Mar 2, 2016·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Maryam SalehiMohammad Mahdi Salehi
Jan 17, 2017·Clinical & Translational Immunology·Zina ValaydonGregor Ebert
Aug 24, 2019·Molecular Genetics & Genomic Medicine·Anna WoziwodzkaKrzysztof Piotr Bielawski
Jul 22, 2018·Journal of Gastrointestinal Cancer·Mehdi Heidari HorestaniMasoud Sheidai

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