Association of TNF-α with impaired migration capacity of mesenchymal stem cells in patients with systemic lupus erythematosus

Journal of Immunology Research
Linyu GengLingyun Sun

Abstract

Previous studies indicated that bone marrow mesenchymal stem cells (BMSCs) from patients with systemic lupus erythematosus (SLE) exhibited impaired capacities of proliferation, differentiation, and immune modulation. Considering that migration capacity is important for the exertion of BMSCs functions, the defects in migration might contribute to BMSCs dysfunction in SLE patients. In this study, we showed that the migration capacity of SLE BMSCs was remarkably impaired in comparison with those of healthy controls. Increased tumor necrosis factor α (TNF-α) in SLE serum significantly inhibited the migration capacity and in vivo homing capacity of SLE BMSCs via a specific TNF receptor I (TNFRI) manner, in which decreased HGF mRNA production caused by the activation of I kappa B kinase beta (IKK-β) pathway is partially involved. To our knowledge, this is the first report to discuss the possible mechanisms for impaired migration of BMSCs in SLE patients. Our results suggest that inhibition of TNF-α pathway might be helpful for accelerating BMSCs migration to the inflammatory microenvironment in SLE patients, thereby having a potential role in SLE treatment.

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Citations

Mar 11, 2018·Journal of Clinical Pathology·Nicole MatejckovaEliska Javorkova
Jul 4, 2019·Journal of Translational Medicine·Madhu Sudhana Saddala, Hu Huang
May 26, 2018·Stem Cell Research & Therapy·Yantong Zhu, Xuebing Feng
Dec 5, 2019·Frontiers in Cell and Developmental Biology·Rui-Juan ChengTony N Marion
Aug 14, 2018·Lupus·P D SattwikaE H Herningtyas
Aug 3, 2019·International Journal of Molecular Sciences·Francisco J VizosoRoman Perez-Fernandez
Dec 6, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Li LiaoYan Jin

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Methods Mentioned

BETA
bone marrow aspiration
Flow Cytometry
Assay
ELISA
electrophoresis
nuclear translocation

Software Mentioned

image pro - plus
Pro Plus
StepOne
Image
GraphPad Prism

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